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2oyc

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structural genomics of protein phosphatases. J.Struct.Funct.Genom. 8 121-140 2007
    Site NYSGXRC
    PDB Id 2oyc Target Id
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    Related PDB Ids 2p69 2p27 
    Molecular Characteristics
    Source
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    Alias Ids
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    TPS7922,PF00702, NP_064711
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.37 Rfactor 0.192
    Waters
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    Solvent Content 48.15

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    Ligand Information
    Ligands WO4 (TUNGSTATE(VI)ION) x 1
    Metals NA (SODIUM) x 1

    Jmol

     
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    Google Scholar output for 2oyc
    1. Structural genomics of protein phosphatases
    SC Almo, JB Bonanno, JM Sauder, S Emtage - Journal of structural and , 2007 - Springer
     
    2. Human HAD phosphatases: structure, mechanism, and roles in health and disease
    A Seifried, J Schultz, A Gohla - FEBS Journal, 2012 - Wiley Online Library
     

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    Protein Summary

    PDXP, also known as chronophin, plays a dual role in vitamin B6 metabolism and serves as a major regulator of the actin cytoskeleton. It was first identified as a pyridoxal phosphatase (dephosphorylating PLP), but has more recently been shown to act as a cofilin phosphatase.

    The structure confirms that it is a member of the haloacid dehalogenase (HAD) family. We also determined structures of the Mg-bound form (PDB: 2p27) and the catalytically insert calcium-bound form (PDB: 2p69). The Ca results in a change of metal ligation from six to seven coordinate via bidentate coordination of the catalytic aspartic acid (Asp25), which results in the loss of activity. PLP is largely buried, with the phosphate completely shielded from solvent.

    After this (2OYC) structure was deposited in the PDB by NYSGXRC, three similar chronophin structures from Kang et al were released from the PDB (2CFR, 2CFS, 2CFT).


    Ligand Summary

    Reviews

    References

     

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