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2isn

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM. 8 121-140 2007
    Site NYSGXRC
    PDB Id 2isn Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS7924,ABV44288.1, PF00481
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.24 Rfactor 0.241
    Waters
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    Solvent Content 44.97

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    Ligand Information
    Ligands SO4 (SULFATE) x 3
    Metals PR (PRASEODYMIUM) x 2

    Jmol

     
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    Google Scholar output for 2isn
    1. Structural genomics of protein phosphatases
    SC Almo, JB Bonanno, JM Sauder, S Emtage - Journal of structural and , 2007 - Springer
     
    2. Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1)
    R Hayashi, K Tanoue, SR Durell, DK Chatterjee - Biochemistry, 2011 - ACS Publications
     

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    Protein Summary

    This is the full length sequence of PP2C2 from Toxoplasma gondii. The gene was codon-optimized and synthesized. Cloning, expression and protein purification was done at SGX Pharmaceuticals and crystallization was done by R. Agarwal in the lab of S. Swaminathan.

    NYSGXRC has completed the structures of three structures from Toxoplasma gondii, including PP2C2 (NYSGXRC-8828z) and PP2C-hn (NYSGXRC-9110a).


    Ligand Summary

    Reviews

    References

     

    No references found.

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