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2hhl

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structural genomics of protein phosphatases. J.STRUCT.FUNCT.GENOM. 8 121-140 2007
    Site NYSGXRC
    PDB Id 2hhl Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS7918,PF03031, NP_001008393
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.35 Rfactor 0.188
    Waters
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    Solvent Content 47.66

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    Ligand Information
    Ligands KEG (12-TUNGSTOPHOSPHATE) x 3
    Metals

    Jmol

     
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    Google Scholar output for 2hhl
    1. Structural genomics of protein phosphatases
    SC Almo, JB Bonanno, JM Sauder, S Emtage - Journal of structural and , 2007 - Springer
     

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    Protein Summary

    The small C-terminal domain phosphatases (SCP) comprise a family of Ser/Thr-specific phosphatases that play a central role in mRNA biogenesis via regulation of RNA polymerase II (RNAP II). The largest subunit of the RNAP II complex has a C-terminal domain (CTD) linked to a region near the RNA exit pore. Reversible phosphorylation of the CTD plays a crucial role in RNAP II progression through the transcription cycle, controlling both transcriptional initiation and elongation. CTD phosphorylation status also affects RNA processing events, such as 5'-capping and 3'-processing. SCP family members also modulate the function of SMAD transcriptional regulators through dephosphorylation.

    SCP family phosphatases are linked to a wide range of physiological responses and pathologic processes. NYSGXRC has determined the structures of both SCP3 (PDB: 2hhl) and SCP2 (PDB: 2q5e). SCP3 has been identified as a tumor suppressor and is frequently deleted or its expression reduced in lung and other major human carcinomas. SCP2 interacts with the androgen receptor and appears to control promoter activity by RNAP II clearance during steroid-responsive transcriptional events.

     



    Ligand Summary

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