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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor. Structure 10 1499-1508 2002
    Site NYSGXRC
    PDB Id 1twi Target Id NYSGXRC-T135
    Related PDB Ids 1tuf 
    Molecular Characteristics
    Source Methanococcus jannaschii
    Alias Ids TPS8101,Q58497 Molecular Weight 48897.17 Da.
    Residues 438 Isoelectric Point 5.78
    Sequence mkimflgndtveikdgrffidgydaielaekfgtplyvmseeqikinynryieafkrweeetgkefiva yaykananlaitrllaklgcgadvvsggelyiaklsnvpskkivfngncktkeeiimgieanirafnvd siselilinetakelgetanvafrinpnvnpkthpkistglkknkfgldvesgiamkaikmalemeyvn vvgvhchigsqltdispfieetrkvmdfvvelkeegieiedvnlggglgipyykdkqiptqkdladaii ntmlkykdkvempnlilepgrslvatagyllgkvhhiketpvtkwvmidagmndmmrpamyeayhhiin ckvknekevvsiagglcessdvfgrdreldkvevgdvlaifdvgaygismannynargrprmvltskkg vflireretyadliakdivpphll
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 4
    Resolution (Å) 2.00 Rfree 0.202
    Matthews' coefficent 2.34 Rfactor 0.157
    Waters 1423 Solvent Content 47.06

    Ligand Information
    Ligands PLP (PYRIDOXAL-5'-PHOSPHATE) x 4;LYS x 6
    Metals MG (MAGNESIUM) x 1


    Google Scholar output for 1twi
    1. Pyridoxal 5-phosphate enzymes as targets for therapeutic agents
    A Amadasi, M Bertoldi, R Contestabile - Current medicinal , 2007 - ingentaconnect.com
    2. PDB_REDO: automated re-refinement of X-ray structure models in the PDB
    RP Joosten, J Salzemann, V Bloch - Journal of Applied , 2009 - scripts.iucr.org
    3. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of LysA (Rv1293) from Mycobacterium tuberculosis
    G Kefala, LJ Perry, MS Weiss - Acta Crystallographica Section F: , 2005 - scripts.iucr.org
    4. The Catalytic Intermediate Stabilized by a Down Active Site Loop for Diaminopimelate Decarboxylase from Helicobacter pylori
    T Hu, D Wu, J Chen, J Ding, H Jiang, X Shen - Journal of Biological , 2008 - ASBMB
    5. Evolution of Substrate Specificity within a Diverse Family of _/_-Barrel-fold Basic Amino Acid Decarboxylases
    X Deng, J Lee, AJ Michael, DR Tomchick - Journal of Biological , 2010 - ASBMB
    6. The three-dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation
    S Weyand, G Kefala, DI Svergun, MS Weiss - Journal of structural and , 2009 - Springer

    Protein Summary

    Ligand Summary




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