The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. Embo J. 23 9-22 2004
    Site NYSGXRC
    PDB Id 1kcx Target Id NYSGXRC-T45
    Molecular Characteristics
    Source Mus musculus
    Alias Ids TPS8090,2342488 Molecular Weight 62103.36 Da.
    Residues 572 Isoelectric Point 7.00
    Sequence mshqgkksiphitsdrllirggriinddqsfyadvyledglikqigenlivpggvktieangrmvipgg idvntylqkpsqgmtsaddffqgtkaalaggttmiidhvvpepgsslltsfekwheaadtksccdyslh vditswydgvreelevlvqdkgvnsfqvymaykdlyqmsdsqlyeaftflkglgavilvhaengdliaq eqkrilemgitgpeghalsrpeeleaeavfraiaiagrincpvyitkvmsksaadiialarkkgplvfg epiaaslgtdgthywsknwakaaafvtspplspdpttpdyltsllacgdlqvtgsghcpystaqkavgk dnftlipegvngieermtvvwdkavatgkmdenqfvavtstnaakifnlyprkgriavgsdadvviwdp dkmktitakshkstveynifegmechgsplvvisqgkivfedgnisvskgmgrfiprkpfpkhlyqrvr irskvsglhsvsrgmydgpvyevpatpkhaapapsaksspskhqpppirnlhqsnfslsgaqiddnnpr rtghrivappggrsnitslg
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.12 Rfree 0.233
    Matthews' coefficent 3.27 Rfactor 0.204
    Waters 804 Solvent Content 62.39

    Ligand Information


    Google Scholar output for 1kcx
    1. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling
    RC Deo, EF Schmidt, A Elhabazi, H Togashi - The EMBO , 2003 - nature.com
    2. Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database
    SCH Pegg, SD Brown, S Ojha, J Seffernick - Biochemistry, 2006 - ACS Publications
    3. The structure of human collapsin response mediator protein 2, a regulator of axonal growth
    P Stenmark, D Ogg, S Flodin, A Flores - Journal of , 2007 - Wiley Online Library
    4. Protein docking using surface matching and supervised machine learning
    AJ Bordner, AA Gorin - Proteins: Structure, Function, and , 2007 - Wiley Online Library
    5. Crystallization and preliminary crystallographic studies of the recombinant dihydropyrimidinase from Sinorhizobium meliloti CECT4114
    S Martnez-Rodrguez - Section F: Structural , 2006 - scripts.iucr.org
    6. Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency
    ABP van Kuilenburg, J Meijer, D Dobritzsch - Molecular genetics and , 2007 - Elsevier
    7. Structure of dihydropyrimidinase from Sinorhizobium meliloti CECT4114: New features in an amidohydrolase family member
    S Martnez-Rodrguez, AI Martnez-Gmez - Journal of structural , 2010 - Elsevier
    8. Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients
    ABP van Kuilenburg, D Dobritzsch, J Meijer - et Biophysica Acta (BBA , 2010 - Elsevier
    9. Factors influencing protein tyrosine nitrationstructure-based predictive models
    AS Bayden, VA Yakovlev, PR Graves - Free Radical Biology , 2011 - Elsevier
    10. Identification of family-specific residue packing motifs and their use for structure-based protein function prediction: II. Case studies and applications
    D Bandyopadhyay, J Huan, J Prins, J Snoeyink - Journal of computer- , 2009 - Springer
    11. Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum
    B Lohkamp, B Andersen, J Piskur - Section F: Structural , 2005 - scripts.iucr.org
    12. Feature amplified voting algorithm for functional analysis of protein superfamily
    CL Hung, C Lee, CY Lin, CH Chang, YC Chung - BMC , 2010 - biomedcentral.com

    Protein Summary

    Ligand Summary




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