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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Proc.Natl.Acad.Sci.USA 99 6949-6954 2002
    Site NYSGXRC
    PDB Id 1jss Target Id NYSGXRC-T526
    Molecular Characteristics
    Source Mus musculus
    Alias Ids TPS8111,Q99JV5 Molecular Weight 25577.76 Da.
    Residues 224 Isoelectric Point 5.45
    Sequence madpespwsqigrkikleglsdvasistklqntliqyhsikedewrvakkvkdvtvwrkpseefngyly kaqgvmddvvnnvidhirpgpwrldwdrlmtsldvlehfeenccvmryttagqllniisprefvdfsyt vgyeegllscgvsvewsetrpefvrgynhpcgwfcvplkdspsqslltgyiqtdlrgmipqsavdtama stlanfysdlrkglrka
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.20 Rfree 0.2850000
    Matthews' coefficent 2.35 Rfactor 0.2380000
    Waters 290 Solvent Content 47.71

    Ligand Information


    Google Scholar output for 1jss
    1. Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain
    MJ Romanowski, RE Soccio - Proceedings of the , 2002 - National Acad Sciences
    2. Structural genomics: a pipeline for providing structures for the biologist
    MR Chance, AR Bresnick, SK Burley, JS Jiang - Protein , 2002 - Wiley Online Library
    3. StAR-like activity and molten globule behavior of StARD6, a male germ-line protein
    S Himangshu, RM Whittal, Y Ran, M Bose - Biochemistry, 2008 - ACS Publications
    4. Structure of a yellow lupin pathogenesis-related PR-10 protein belonging to a novel subclass
    O Pasternak, J Biesiadka, R Dolot - Section D: Biological , 2004 - scripts.iucr.org
    5. Structural insight into the self-sacrifice mechanism of enediyne resistance
    S Singh, MH Hager, C Zhang, BR Griffith, MS Lee - 2006 - ACS Publications
    6. VASP: a volumetric analysis of surface properties yields insights into protein-ligand binding specificity
    BY Chen, B Honig - PLoS computational biology, 2010 - dx.plos.org
    7. Mammalian StAR-related lipid transfer (START) domains with specificity for cholesterol: structural conservation and mechanism of reversible binding
    P Lavigne, R Najmanivich, JG LeHoux - Cholesterol Binding and , 2010 - Springer
    8. NMR structure of the 18 kDa protein CC1736 from Caulobacter crescentus identifies a member of the START domain superfamily and suggests residues mediating
    Y Shen, S Goldsmith_Fischman - Proteins: Structure, , 2005 - Wiley Online Library
    9. Efficient recognition of protein fold at low sequence identity by conservative application of Psi_BLAST: validation
    FJ Stevens - Journal of Molecular Recognition, 2005 - Wiley Online Library
    10. Comparative structural analysis of lipid binding START domains
    AG Thorsell, WH Lee, C Persson, MI Siponen - PloS one, 2011 - dx.plos.org
    11. High-throughput computational structure-based characterization of protein families: START domains and implications for structural genomics
    H Lee, Z Li, A Silkov, M Fischer, D Petrey - Journal of structural and , 2010 - Springer
    12. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas
    YX He, L Huang, Y Xue, X Fei, YB Teng - Journal of Biological , 2010 - ASBMB
    13. Site-directed mutagenesis and structural modeling of Coq10p indicate the presence of a tunnel for coenzyme Q6 binding
    C Busso, L Bleicher, JR Ferreira-Jnior, MH Barros - FEBS letters, 2010 - Elsevier
    14. A fourier fingerprint-based method for protein surface representation
    MJ Bayley, EJ Gardiner, P Willett - Journal of chemical , 2005 - ACS Publications
    15. Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (
    M Nakabayashi, N Shibata, H Komori - Section F: Structural , 2005 - scripts.iucr.org
    16. Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design
    N Akula, A Midzak, L Lecanu - Bioorganic & medicinal , 2012 - Elsevier
    17. 1 H, 13 C, and 15 N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4)
    I Dikiy, TF Ramlall, D Eliezer - Biomolecular NMR Assignments, 2012 - Springer
    18. Recombinant protein variants
    J Holm, JN Larsen - EP Patent 2,270,164, 2011 - freepatentsonline.com

    Protein Summary

    Ligand Summary




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