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2nw8

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Proc.Natl.Acad.Sci.Usa 104 473-478 2007
    Site NESGC
    PDB Id 2nw8 Target Id
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    Related PDB Ids 2nw9 1yw0 2nw7 
    Molecular Characteristics
    Source
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    Alias Ids
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    TPS9253,PF03301
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.50 Rfactor 0.171
    Waters
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    Solvent Content 50.81

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    Ligand Information
    Ligands TRP (PROTOPORPHYRIN) x 4;HEM x 2
    Metals MN (MANGANESE) x 2

    Jmol

     
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    Google Scholar output for 2nw8
    1. Molecular insights into substrate recognition and catalysis by tryptophan 2, 3-dioxygenase
    F Forouhar, JL Anderson, CG Mowat - Proceedings of the , 2007 - National Acad Sciences
     
    2. Substrate_ Protein Interaction in Human Tryptophan Dioxygenase: The Critical Role of H76
    D Batabyal, SR Yeh - Journal of the American Chemical Society, 2009 - ACS Publications
     
    3. ONIOM study on a missing piece in our understanding of heme chemistry: Bacterial tryptophan 2, 3-dioxygenase with dual oxidants
    LW Chung, X Li, H Sugimoto, Y Shiro - Journal of the , 2010 - ACS Publications
     
    4. The second enzyme in pyrrolnitrin biosynthetic pathway is related to the heme-dependent dioxygenase superfamily
    W De Laurentis, L Khim, JLR Anderson, A Adam - Biochemistry, 2007 - ACS Publications
     
    5. Molecular docking and spatial coarse graining simulations as tools to investigate substrate recognition, enhancer binding and conformational transitions in
    A Macchiarulo, R Nuti, D Bellocchi, E Camaioni - et Biophysica Acta (BBA , 2007 - Elsevier
     
    6. A knowledge-driven approach for crystallographic protein model completion
    K Joosten, SX Cohen, P Emsley, W Mooij - Section D: Biological , 2008 - scripts.iucr.org
     
    7. The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2, 3-dioxygenase as revealed by quantum mechanical/molecular
    L Capece, A Lewis-Ballester, D Batabyal - Journal of Biological , 2010 - Springer
     
    8. Ligand and substrate migration in human indoleamine 2, 3-dioxygenase
    E Nickel, K Nienhaus, C Lu, SR Yeh - Journal of Biological , 2009 - ASBMB
     
    9. Substrate stereo_specificity in tryptophan dioxygenase and indoleamine 2, 3_dioxygenase
    L Capece, M Arrar, AE Roitberg, SR Yeh - Proteins: Structure, , 2010 - Wiley Online Library
     
    10. The Complete Reaction Mechanism of Indoleamine 2, 3-Dioxygenase as Revealed by QM/MM Simulations
    L Capece, A Lewis-Ballester, SR Yeh - The Journal of , 2012 - ACS Publications
     
    11. Molecular basis for the substrate stereoselectivity in Tryptophan Dioxygenase
    L Capece, A Lewis-Ballester, MA Marti, DA Estrin - Biochemistry, 2011 - ACS Publications
     
    12. Biochemical and Spectroscopic Characterization of Tryptophan Oxygenation: Tryptophan 2, 3-Dioxygenase and Maug
    R Fu - 2009 - digitalarchive.gsu.edu
     
    13. Non-canonical interactions of porphyrins in porphyrin-containing proteins
    S_ Stojanovi_, ER Isenovi_, BL Zari_ - Amino Acids, 2012 - Springer
     
    14. Interactions of Metals and Radicals: A Biochemical Perspective in Tryptophan Dioxygenase
    K Dornevil - 2011 - digitalarchive.gsu.edu
     
    15. Towards a Unified View of Substrate Binding in Heme Peroxidases.
    EJ Murphy - 2009 - lra.le.ac.uk
     
    16. The Oxidation of L-Tryptophan in Biology by Human Heme Dioxygenases
    BSA Rafice - 2010 - lra.le.ac.uk
     

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    Protein Summary


    Ligand Summary

    Reviews

    References

     

    No references found.

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