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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase. Proc.Natl.Acad.Sci.USA 97 2017-2022 2000
    Site NESGC
    PDB Id 1dv7 Target Id TT2
    Molecular Characteristics
    Source Methanothermobacter thermautotrophicus
    Alias Ids TPS9199,PF00215, Molecular Weight 24723.05 Da.
    Residues 227 Isoelectric Point 5.02
    Sequence rsrrvdvmdvmnrlilamdlmnrddalrvtgevreyidtvkigyplvlsegmdiiaefrkrfgcriiad fkvadipetnekicratfkagadaiivhgfpgadsvraclnvaeemgrevflltemshpgaemfiqgaa deiarmgvdlgvknyvgpstrperlsrlreiigqdsflispgvgaqggdpgetlrfadaiivgrsiyla dnpaaaaagiiesikdllnp
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.80 Rfree 0.2220000
    Matthews' coefficent 2.03 Rfactor 0.2000000
    Waters 217 Solvent Content 39.45

    Ligand Information


    Google Scholar output for 1dv7
    1. Computer simulations of enzyme catalysis: methods, progress, and insights
    A Warshel - Annual review of biophysics and biomolecular , 2003 - annualreviews.org
    2. Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase
    N Wu, Y Mo, J Gao, EF Pai - Proceedings of the National , 2000 - National Acad Sciences
    3. Structural proteomics of an archaeon
    D Christendat, A Yee, A Dharamsi, Y Kluger - nature structural , 2000 - pdg.cnb.uam.es
    4. Structural proteomics: toward high-throughput structural biology as a tool in functional genomics
    A Yee, K Pardee, D Christendat - Accounts of chemical , 2003 - ACS Publications
    5. Effective factors in thermostability of thermophilic proteins
    M Sadeghi, H Naderi-Manesh, M Zarrabi - Biophysical chemistry, 2006 - Elsevier
    6. Circe effect versus enzyme preorganization: what can be learned from the structure of the most proficient enzyme?
    A Warshel, J Florin, M trajbl, J Vill - ChemBioChem, 2001 - Wiley Online Library
    7. A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity
    AM Bello, E Poduch, M Fujihashi, M Amani - Journal of medicinal , 2007 - ACS Publications
    8. Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase
    P Harris, JCN Poulsen, KF Jensen, S Larsen - Journal of molecular biology, 2002 - Elsevier
    9. Structural basis for the decarboxylation of orotidine 5_-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase
    K Tokuoka, Y Kusakari, SR Krungkrai - Journal of , 2008 - Jpn Biochemical Soc
    10. Mechanism of the orotidine 5_-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization
    KK Chan, BMK Wood, AA Fedorov, EV Fedorov - Biochemistry, 2009 - ACS Publications
    11. Structure and Inhibition of Orotidine 5_-Monophosphate Decarboxylase from Plasmodium falciparum
    DB Langley, M Shojaei, C Chan, HC Lok - Biochemistry, 2008 - ACS Publications
    12. Computer-based screening of functional conformers of proteins
    HMM Molina, C Milln-Pacheco, N Pastor - PLoS Computational , 2008 - dx.plos.org
    13. Pyrimidine Derivatives As Anticancer Agents
    LP Kotra, EF Pai, CJ Paige, AM Bello - US Patent App. 12/522,511, 2008 - Google Patents
    14. pK (a) prediction of residues in proteins and theoretical studies of enzyme mechanisms
    CL Stanton - 2007 - books.google.com
    15. _________________
    ___ ____ ___ ____ ____ ___ - ____, 2010 - sioc-journal.cn
    16. Crystallographic structure refinement
    P Afonine - phenix-online.org
    17. Iterative Protein Alignment Algorithm (IPA)
    TV Kirys, SI Feranchuk, AV Tuzikov, J Rocha - dmi.uib.es

    Protein Summary

    Ligand Summary




    No references found.

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