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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants. J.Biol.Chem. 283 2835-2845 2008
    Site MCSG
    PDB Id 1x92 Target Id APC5045
    Related PDB Ids 3bjz 
    Molecular Characteristics
    Source Pseudomonas aeruginosa pa01
    Alias Ids TPS4655,AAG07813, 208964 Molecular Weight 21412.13 Da.
    Residues 197 Isoelectric Point 5.00
    Sequence mdmqhrirqlfqasietkqqalevlppyieqaslvmvnallnegkilscgnggsagdaqhfssellnrf ererpslpavalttdsstitsiandysynevfskqiralgqpgdvllaistsgnsanviqaiqaahdre mlvvaltgrdgggmaslllpedveirvpskitariqevhllaihclcdlidrqlfgsee
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.30 Rfree 0.221
    Matthews' coefficent 3.01 Rfactor 0.176
    Waters 196 Solvent Content 59.17

    Ligand Information


    Google Scholar output for 1x92
    1. The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATPDnaA-specific initiation complexes
    K Keyamura, N Fujikawa, T Ishida, S Ozaki - Genes & , 2007 - genesdev.cshlp.org
    2. Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants
    PL Taylor, KM Blakely, GP de Leon, JR Walker - Journal of Biological , 2008 - ASBMB
    3. Structural similarity between the DnaA_binding proteins HobA (HP1230) from Helicobacter pylori and DiaA from Escherichia coli
    G Natrajan, DR Hall, AC Thompson - Molecular , 2007 - Wiley Online Library
    4. N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism
    T Jaeger, C Mayer - Cellular and Molecular Life Sciences, 2008 - Springer
    5. Ligands in PSI structures
    A Kumar, HJ Chiu, HL Axelrod, A Morse - Section F: Structural , 2010 - scripts.iucr.org
    6. The Structure of Sedoheptulose-7-Phosphate Isomerase from Burkholderia pseudomallei Reveals a Zinc Binding Site at the Heart of the Active Site
    NJ Harmer - Journal of molecular biology, 2010 - Elsevier
    7. Crystal structures of two putative phosphoheptose isomerases
    J Seetharaman, KR Rajashankar - Proteins: Structure, , 2006 - Wiley Online Library
    8. Crystal structure of YfeU protein from Haemophilus influenzae: a predicted etherase involved in peptidoglycan recycling
    Y Kim, P Quartey, R Ng, TI Zarembinski - Journal of structural and , 2009 - Springer
    9. Crystallographic and NMR Studies of Aquifex Aeolicus Phosphoheptose Isomerase: Structural Insights into the Mechanism of Aldose-Ketose Isomerization.
    V Thai, G Petsko, D Kern - The role of structure and dynamics in , 2007 - books.google.com

    Protein Summary

    Ligand Summary




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