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PDB Keyword
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4fuu

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Site JCSG
    PDB Id 4fuu Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    reference to undefined name 'note' Exception of type 'MindTouch.Deki.Script.Runtime.DekiScriptUndefinedNameException' was thrown. (click for details)
    TPS66815,NP_811461.1, 3.40.630.10, 332525
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method
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    Chains
    Resolution (Å)
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    Rfree
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    Matthews' coefficent Rfactor
    Waters
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    Solvent Content

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 4fuu

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    Protein Summary

    Target ID 417178 is a member of the Peptidase_M28 (PF04389) Pfam family. This Pfam family is represented by over 113 structures in the PDB. A more detailed description from the Interpro database on the structure and function of members of this clan are found here. Shown below is a ribbons representation of the structure with the N-terminal end in blue and the C-terminal end in red.

     

    ribbons.png

    A bound metal atom (most likely Zn) is depicted by a grey sphere. The structure of target ID 417178 shows a Phosphorylase/hydrolase-like fold and a member of the Zn-dependent exopeptidase Superfamily

    The structure of target ID 417178 is quite similar to those of two other JCSG targets represented by PDB ID 3tc8 and 3gux. Shown below are the top-scoring structures similar to that of target ID 417178 determined from a DALI search.

    PDB ID DALI Z-score residues aligned residues in related structure rmsd overlap (Ang) % sequence id Description
    3tc8 50.9 286 293 0.8 60 Hypothetical Zn-dependent exopeptidase (BDI_3547) from Parabacteroides distasonis ATCC 8503 at 1.06 A resolution
    3gux 42.4 246 247 0.8 67 putative Zn-dependent exopeptidase (YP_001298628.1) from Bacteroides vulgatus ATCC 8482 at 1.80 A resolution
    2ek8 32.0 249 412 2.1 23 Structural characterization of a novel bacterial aminopeptidase with an apical domain from aneurinibacillus sp. strain AM-1
    3pb6 32.0 263 313 2.4 19 Crystal structure of the catalytic domain of human Golgi-resident glutaminyl cyclase at pH 6.5.[Ref]
    3si2 31.9 262 322 2.4 19 Structure of glycosylated murine glutaminyl cyclase in presence of the inhibitor PQ50 (PDBD150). [Ref]
    2afu 30.9 261 322 2.4 18 Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester. [Ref]
    2zen 30.7 261 261 2.5 19 Crystal structure of the human glutaminyl cyclase mutant D305A at 1.78 angstrom resolution. [Ref]
    1lok 30.7 250 250 2.2 18 The 1.20 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica Complexed with Tris: A Tale of Buffer Inhibition. [Ref]
    3b7i 30.7 250 250 2.2 18 Crystal structure of the S228A mutant of the aminopeptidase from Vibrio proteolyticus in complex with leucine phosphonic acid[Ref]

     

     

     

     

     

     

    Ligand Summary

    Reviews

    References

     

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