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The Open Protein Structure Annotation Network
PDB Keyword
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4fm3

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of a hypothetical protein (PA2901) from Pseudomonas aeruginosa PAO1 at 2.47 A resolution. To be published
    Site JCSG
    PDB Id 4fm3 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS74327,NP_251591.1, 328114
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.63 Rfactor 0.2018
    Waters
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    Solvent Content 53.15

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 4fm3

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    Protein Summary

    Pfam Update: I have searched it on the web-site and find it hits DUF4398 PF14346 DUF4398 Domain of unknown function (DUF4398) Family n/a 1 91 2 91 13 103 70.6 8.4e-20 There are no structures for this DUF.

     

    Shown below is a ribbons representation of the structure of target id 417371. The structure presented here represents the first for the DUF4398 Pfam Family. The monomeric structure consists of three alpha-helicies with the C-terminal helix significantly longer than the other two.

     

    monomer.png

     

    The crystal structure suggests that the tetramer is a significant oligomerization state

     

    tetramer.png

    A DALI structural similarity search shows the following similarities

     

    3gru_to_SP19308B.png

     

     

    green-target ID 417371

    The cyan structure represents PDB ID 3rgu, the fimbriae-associated protein 1 (Fap1), a major adhesin of Streptococcis parasanguins.[Ref] (DALI Z-score 6.3, rmsd overlap 2.9 Ang, alignment length=71 residues, sequence id=10%). Note that both proteins contain a similar three-helix bundle architecture. The most significant difference between the two structures is that target id 417371 contains a longer C-terminal helix. The crystal structure of target id 417371 suggests this longer helix may play a role in tetrameric assembly.The structural similarity suggests that target id 417371 might play a role in biofilm formation by Peudomonas aeruginosa.

     

    3t47_to_SP19308B.png
    green-target id 417371

    cyan-PDB ID 3t47, a truncated form of the Staplyococcal Complement Inhibitor D (SCIN-D) [Ref] (DALI Z score 5.7, rmsd overlap=2.5 Angstroms, length of alignment=59 residues, sequence id=5%)

     

     

    Ligand Summary

    Reviews

    References

     

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