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PDB Keyword
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3pxp

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes. Plos One 7 e41359-e41359 2012
    Site JCSG
    PDB Id 3pxp Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    reference to undefined name 'note' Exception of type 'MindTouch.Deki.Script.Runtime.DekiScriptUndefinedNameException' was thrown. (click for details)
    TPS6410,YP_001635876.1, 103333, 103772
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 3
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.45 Rfactor 0.168
    Waters
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    Solvent Content 49.84

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3pxp
    1. Structure of an MmyB-Like Regulator from C. aurantiacus, Member of a New Transcription Factor Family Linked to Antibiotic Metabolism in Actinomycetes
    Q Xu, GP van Wezel, HJ Chiu, L Jaroszewski, HE Klock - PloS one, 2012 - dx.plos.org
     

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    Protein Summary

    The Caur_2278 (GI:163847832, accession YP_001635876.1, refseq NC_010175.1) protein from Chloroflexus aurantiacus J-10-fl belongs to the Xre (NOTE: Xre is a protein name, not xenobiotic response element) transcription factor family, and contains a N-terminal Xre HTH domain and a C-terminal PAS-like domain.  This is a large (>1000 members) family of proteins, found in very diverse bacteria, from proteobacteria to firmicutes to actinobacteria. The PAS-domain has a myristic acid in the substrate binding site.

     

    The protein in the crystal is a dimer, it is speculated that dimer is promoted by ligand binding of the PAS domain.

     

    Fig. 1. dimer with fatty acid (shown as sticks)

    fj9298a.png

    Ligand Summary

    Reviews

    References

     

    No references found.

    Tag page
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    Files (1)

    FileSizeDateAttached by 
     fj9298a.png
    fj9298a dimer
    194.21 kB20:29, 2 Nov 2010qxuActions
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