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The Open Protein Structure Annotation Network
PDB Keyword
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3lov

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of Putative protoporphyrinogen oxidase (YP_001813199.1) from Exiguobacterium sp. 255-15 at 2.06 A resolution. To be published
    Site JCSG
    PDB Id 3lov Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS25448,YP_001813199.1, 332878
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.79 Rfactor 0.197
    Waters
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    Solvent Content 55.91

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3lov
    1. Data processing and analysis with the autoPROC toolbox
    C Vonrhein, C Flensburg, P Keller, A Sharff - Section D: Biological , 2011 - scripts.iucr.org
     
    2. FAD-binding site and NAD (P) reactivity in human renalase, a new enzyme involved in blood pressure regulation
    M Milani, F Ciriello, S Baroni, V Pandini - Journal of Molecular , 2011 - Elsevier
     

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    Protein Summary

    This protein is a protoporphyrinogen oxidase (PPO) based on high sequence similarity to B. subtilis enzyme 3i6d (40% id, Pubmed id: 19944166), which an important enzyme in the biosynthesis of heme/chlorophyll. It is also homologous to plant PPO (PDB 1sez, 21% seq, Pubmed  15057273).

     

    As expected, the structure is highly similar to the BsPPO. There is no ligand in the jcsg structure, except for co-factor FAD. The main value of this structure is that is an apo form, which displays a closed active site, suggesting conformational changes are needed for substrate binding.

     

    This protein is now in family PF01593.17 Amino_oxidase CL0063 along with other structures.

     

    Fig 1. PPO with FAD
    ge8204a.png

    Ligand Summary

    Reviews

    References

     

    No references found.

    Tag page

    Files (1)

    FileSizeDateAttached by 
     ge8204a.png
    ge8204a monomer
    165.63 kB20:48, 1 Feb 2010qxuActions
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