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The Open Protein Structure Annotation Network
PDB Keyword
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3lhn

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of putative lipoprotein (NP_718719.1) from Shewanella oneidensis at 1.42 A resolution. To be published
    Site JCSG
    PDB Id 3lhn Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS6201,NP_718719.1, PF04170
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.02 Rfactor 0.172
    Waters
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    Solvent Content 38.96

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3lhn

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    Protein Summary

    Pfam Update: This protein is no in Family: NlpE (PF04170) which already has a few structures.

     

    Gene SO_3163 from SHEWANELLA ONEIDENSIS encodes the NP_718719.1 protein with 150 residues and an isoelectric point of 4.77.  The NCBI blast sequence alignment indicates that this protein contains a putative conserved domain belonging to NlpE superfamily. Accordingly, NP_718719.1 sequence belongs to the uncharacterized lipoprotein NlpE group involved in copper resistance (PF04170). Analysis of its genome context by STRING provides a hit with the neighboring sensor histidine kinase NP_718718.

     

    3lhn is a structurally similar (Dali Z-scr=11) to the Cpx Pathway Activator NlpE on the Outer Membrane of Escherichia coli (PDB ID: 2Z4H) [Ref].  As seen in 2z4h, the crystal interface interaction suggests that the biomolecule of 3lhn is a dimer.

     

    365930_2.png

     

    Figure 1. 3lhn monomer folds into a beta-barrel core.

     

     

    365930_1.png

     

    Figure 2. The biologically relevant dimer of 3lhn.

     

    365930_3.png

    Figure 3.  3hln (green) has a similar structure compared to 2z4h (pink).

    Ligand Summary

    Reviews

    References

     

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