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3k7c

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of Putative NTF2-like transpeptidase (NP_281412.1) from CAMPYLOBACTER JEJUNI at 2.00 A resolution. To be published
    Site JCSG
    PDB Id 3k7c Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS26539,NP_281412.1, 325558
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.30 Rfactor 0.214
    Waters
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    Solvent Content 46.46

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3k7c

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    Protein Summary

    Protein Cj0202c (JCSG target ID 391926, JCSG target accession code FR15108A, GenBank accession code NP_281412.1) is a 113-residue long protein from Campylobacter jejuni, a gram-negative bacterium that is the most common causes of human gastroenteritis.

    According to Pfam, Cj0202c belongs to a family of putative lipoproteins from bacteria (Pfam CL0051). Many members of the family are defined as having a lumazine-binding domain. Lumazine is a fluorescent accessory protein having 6,7-dimethyl-8-(1'-D-ribityl) lumazine (DMRL) as its authentic chromophore; it modulates the emission of bacterial luciferase to shorter wavelengths with increasing luminous strength. The family is related to the NTF2-like transpeptidase family.

    The structure of Cj0202c, solved by Se-MAD to a resolution of 2.0 Angstroms, adopts an alpha/beta fold that can be classified as belonging to the nuclear transport factor 2 (NTF2)-like superfamily in SCOP (Figure 1).[1]

    Figure 1.  Structure of Cj0202c gradiently colored from the N- (blue) to the C-terminus (red).

    FR15108A-gradient.png

    A Dali search results in a number of structural neighbors that also adopt the NTF2-like fold (Table 1 and Figure 2).

    Table 1.  Structural neighbors of Cj0202c as assessed by Dali.

    N PDB Z-score RMSD LALI NRES %ID TITLE
    1 3gwr 9.6 2.7 99 128 8 PUTATIVE CALCIUM/CALMODULIN-DEPENDENT PROTEIN
    2 3bb9 9.6 2.5 97 120 16 PUTATIVE ORPHAN PROTEIN
    3 3d9r 9.5 2.6 96 130 15 KETOSTEROID ISOMERASE-LIKE PROTEIN
    4 2jq5 9.5 2.4 93 128 11 SEC-C MOTIF
    5 3fka 9.2 2.9 91 120 12 UNCHARACTERIZED NTF-2 LIKE PROTEIN
    6 2i9w 8.9 2.3 93 177 12 HYPOTHETICAL PROTEIN
    7 2owp 8.8 2.8 95 129 8 HYPOTHETICAL PROTEIN BXE_B1374
    8 2f86 8.7 4.1 97 129 10 HYPOTHETICAL PROTEIN K11E8.1D
    9 2rcd 8.6 2.9 95 128 11 UNCHARACTERIZED PROTEIN
    10 1mws 8.6 3.1 95 634 11 PENICILLIN-BINDING PROTEIN 2A

     

    Figure 2.  Superposition of Cj0202c (green) with several top structural neighbors: 3gwr (cyan); 3bb9 (magenta); 3d9r (yellow); 2jq5 (salmon); 3fka (gray).

    FR15108A-superpose.png

    A genome context analysis with STRING reveals that Cj0202c may be functional partners with Cj0201c (a putative integral membrane protein), Cj0200c (a putative periplasmic protein), and Cj0203 (a putative transmembrane transport protein).

    Ligand Summary

    Reviews

    References

     

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