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The Open Protein Structure Annotation Network
PDB Keyword
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3jtx

    Title Crystal structure of Aminotransferase (NP_283882.1) from NEISSERIA MENINGITIDIS Z2491 at 1.91 A resolution. To be published
    Site JCSG
    PDB Id 3jtx Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS14630,NP_283882.1, 3.40.640.10, 289384
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.68 Rfactor 0.152
    Waters
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    Solvent Content 54.09

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3jtx

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    Protein Summary

    The protein NP_283882.1 is annotated as putative aminotransferase. NP_283882.1 belongs to PFAM PF00155 Aminotran_1_2 which consists of mainly amino-transferases.

    The monomer structure is shown below.

    MG14465E_mon.pngMG14465E_llp1.png

    The residue Lys 244 is covalently linked with PLP, shown abobe in stick representation. A buffer molecule MES from the crystallization solution is located next to PLP in both monomers in the crystal structure (zoomed view on the right) . The MES molecule may mimic a substrate.

     

    The dimeric structure is shown below.

    MG14465E_dimer2.png

     

     

    DALI Structural Homologs

    N PDB Z-score RMSD LALI NRES %ID TITLE (JCSG structures highlighted in red)
    1 3ezs 50.0 1.7 369 374 38 AMINOTRANSFERASE ASPB
    2 2o1b 46.6 2.1 368 376 26 AMINOTRANSFERASE, CLASS I
    3 1gde 45.6 2.6 370 388 24 ASPARTATE AMINOTRANSFERASE
    4 1gd9 45.6 2.6 370 388 24 ASPARTATE AMINOTRANSFERASE
    5 2dou 45.2 2.5 366 372 27 PROBABLE N-SUCCINYLDIAMINOPIMELATE
    6 1o4s 44.3 2.6 368 375 21 ASPARTATE AMINOTRANSFERASE
    7 1dju 44.2 2.4 360 375 24 AROMATIC AMINOTRANSFERASE
    8 2o0r 44.1 2.7 370 385 22 RV0858C (N-SUCCINYLDIAMINOPIMELATE
    9 1xi9 44.1 2.5 367 393 21 PUTATIVE TRANSAMINASE
    10 2gb3 43.5 2.7 373 394 24 ASPARTATE AMINOTRANSFERASE

    Ligand Summary

     

     

    Literature references

    1. Nakai T, Okada K, Akutsu S, Miyahara I, Kawaguchi S, Kato R, Kuramitsu S, Hirotsu K; , Biochemistry 1999;38:2413-2424.: Structure of Thermus thermophilus HB8 aspartate aminotransferase and its complex with maleate. PUBMED:10029535

    2. Ko TP, Wu SP, Yang WZ, Tsai H, Yuan HS; , Acta Crystallogr D Biol Crystallogr 1999;55:1474-1477.: Crystallization and preliminary crystallographic analysis of the Escherichia coli tyrosine aminotransferase. PUBMED:10417420

    Reviews

    References

     

    No references found.

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