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3e8o

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of protein of unknown function with ferredoxin-like fold (NP_295823.1) from DEINOCOCCUS RADIODURANS at 1.40 A resolution. To be published
    Site JCSG
    PDB Id 3e8o Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS14623,NP_295823.1, 3.30.70.900, 85707
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 1.79 Rfactor 0.128
    Waters
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    Solvent Content 31.47

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3e8o
    1. Ligands in PSI structures
    A Kumar, HJ Chiu, HL Axelrod, A Morse - Section F: Structural , 2010 - scripts.iucr.org
     
    2. Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers
    H Van Den Bedem, A Dhanik, JC Latombe - Section D: Biological , 2009 - scripts.iucr.org
     
    3. A novel approach to studying the structural and functional properties of proteins with unknown functions
    MA Gorbacheva, AG Yarosh, PV Dorovatovskii - Russian Journal of , 2012 - Springer
     

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    Protein Summary

    Protein of unknown function with ferredoxin-like fold (GenBank: NP_295823.1) isan uncharacterized protein that belongs to PFAM PF03992. This is the antibiotic biosynthesis monooxygenase family, and this domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species.

    MG14516A_dimer.png

    Fig 1. The protein is dimeric in organization with the two monomers forming a barrel. The last strand of each monomer extends to the other in the dimerization process.

        

    There are numerous structural homologs of this protein. Fig 2. shows teh superposition of some of these proteins.

    all.png

    Fig 2. Superposition of structural homologs: this target (green), 1tuv (cyan), 1x7v (magenta), 1y0h (yellow), 2fb0 (pink), 2gff (grey), 2omo (blue), 2pd1 (orange), 3bm7 (lime).

    all_as.png UNL_DM.png

                                  A                                                                                        B 

    Fig 3. A. Some of these proteins have some ligands bound in the core of the protein suggesting the location of the active site. B. An unknown ligand (UNL) (shown as red spheres) has been modeled in the unbiased density (DM density prior to model building) in this region in this protein (green). Structure 1tuv (cyan) has been superimposed on the target to show the binding of the ligand VK3 (shown in sticks) in 1tuv at the same site.

    Ligand Summary

    Unknown ligand (UNL)

    Reviews

    References

     

    No references found.

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