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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of 4-methyl-5-(beta-hydroxyethyl)thiazole kinase (NP_816404.1) from ENTEROCOCCUS FAECALIS V583 at 2.57 A resolution. To be published
    Site JCSG
    PDB Id 3dzv Target Id 375214
    Molecular Characteristics
    Source Enterococcus faecalis v583
    Alias Ids TPS16169,NP_816404.1, 3.40.1190.20, 104040 Molecular Weight 29717.45 Da.
    Residues 272 Isoelectric Point 4.85
    Sequence mktsvkfetifplttapliqcitneitcesmanallyidakpimaddprefpqmfqqtsalvlnlghls qereqsllaasdyarqvnkltvvdlvgygasdirnevgeklvhnqptvvkgnlsemrtfcqlvshgrgv dgspldqseeaieeliqalrqqtqkfpqtvflatgiqdvlvsqeqvivlqngvpeldcftgtgdlvgal vaallgegnapmtaavaavsyfnlcgekaktksqgladfrqntlnqlsllmkekdwfeavkgrvl
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.57 Rfree 0.204
    Matthews' coefficent 4.15 Rfactor 0.175
    Waters 124 Solvent Content 70.35

    Ligand Information


    Google Scholar output for 3dzv
    1. New structural insights and molecular-modelling studies of 4-methyl-5--hydroxyethylthiazole kinase from Pyrococcus horikoshii OT3 (PhThiK)
    J Jeyakanthan, S Thamotharan - Section F: Structural , 2009 - scripts.iucr.org
    2. Purification, crystallization and preliminary X-ray diffraction analysis of ThiM from Staphylococcus aureus
    J Drebes, M Perbandt, C Wrenger - Section F: Structural , 2011 - scripts.iucr.org

    Protein Summary

    The EF_2777 gene from Enterococcus faecalis v583 encodes a hydroxyethylthiazole kinase (PF02110, COG2145, EC, adopts a ribokinase-like fold and shows strong structural similarity with other hydroxyethylthiazole kinase structures determined by structural genomics (e.g. PDB id: 1V8A, FATCAT P-value 0.0). Genome context, structural similarity and homology suggest that EF_2777 is 4-methyl-5-beta-hydroxyethylthiazole kinase (ThiK), a salvage enzyme in the thiamine biosynthesis pathway [Ref].

    Ligand Summary




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