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The Open Protein Structure Annotation Network
PDB Keyword
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3do6

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Title Crystal structure of Putative Formyltetrahydrofolate Synthetase (TM1766) from THERMOTOGA MARITIMA at 1.85 A resolution. To be published
    Site JCSG
    PDB Id 3do6 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS9370,TM1766, 29346147, 282821
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.51 Rfactor 0.162
    Waters
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    Solvent Content 51.05

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3do6
    1. A structural bioinformatics approach to explore the interactions of P53 and BRCA1 gene products on ovarian and breast cancer
    S Parija, A Kumar - International Journal of Bioinformatics Research , 2011 - Inderscience
     
    2. New Protein Structure Model Evaluation Methods That Include a Side-Chain Consensus Score for the Protein Modeling
    K Kanou, T Hirata, G Terashi, H Umeyama - Chemical and , 2010 - J-STAGE
     
    3. Protein Physics by Advanced Computational Techniques: Conformational Sampling and Folded State Discrimination
    PC Tejada - 2011 - sissa.it
     
    4. Molecular evolutiondirected approach for designing archaeal formyltetrahydrofolate ligase
    P Chellapandi, J Balachandramohan - Turk J Biochem, 2011 - oaj.unsri.ac.id
     
    5. A New Library of Surface Patches: Design and Applications
    R Gamliel, K Kedem, R Kolodny, C Keasar - 2009 - cs.bgu.ac.il
     

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    Protein Summary

    283620 is annotated as formate-tetrahydrofolate ligase. The structure is very similar with 1fpm (rmsd 1.06A for 534 aligned Ca atoms) and 1fp7 (rmsd 1.07A for 533 aligned Ca atoms).

    Fig. 1. Superposition of 283620 (green) with 1fpm (yellow) and 1fp7(pink) structures.

    The asu of 283620 contains a dimer. However, biological molecule of 283620 is a tetramer similar as other tetrahydrofolate ligase.

    Fig. 2. Dimer of 283620 in asu is shown. Green and cyan represent A and B subunits, respectively.


    Fig. 3. Biological tetramer of 283620 is shown. Green, cyan, pink and yellow represent A, B,A' and B' subunits, respectively.

    Ligand Summary

    Ethylene glycol (EDO) molecules from cryo solution were modeled.

    Reviews

    References

     

    No references found.

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