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The Open Protein Structure Annotation Network
PDB Keyword
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3cin

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of MYO-inositol-1-phosphate synthase-related protein (TM1419) from Thermotoga maritima at 1.70 A resolution. To be published
    Site JCSG
    PDB Id 3cin Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1286,TM1419, 84803
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 1
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.43 Rfactor 0.160
    Waters
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    Solvent Content 49.47

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 3cin
    1. Pyridobenzothiazole derivatives as new chemotype targeting the HCV NS5B polymerase
    G Manfroni, F Meschini, ML Barreca, P Leyssen - Bioorganic & Medicinal , 2011 - Elsevier
     

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    Protein Summary

    The gene TM1419 from Thermotoga maritima encodes the NP_229219 protein, an inositol-3-phosphate synthase EC:5.5.1.4 PF01658. Analysis by SCOP indicates that the inositol-3-phosphate synthase from Thermotoga maritima has two structural domains: N-terminal domain (1-209) belongs to the NAD(P)-binding Rossmann-fold domain superfamily, glyceraldehyde-3-phosphate dehydrogenase-like N-terminal domain family (SCOP51734); the C-terminal domain (211-316) belongs to the gyceraldehyde-3-phosphate dehydrogenase-like C-terminal domain superfamily, dihydrodipicolinate reductase-like family. According to DALI, similar structures are: 1JKI (Z=36), 1U1I (Z=41), and 1GR0 (Z=29).

    The enzyme catalyzes the conversion of D-glucose 6-phosphate to 1-L-myo-inositol-1-phosphate (MIP), the first and rate-limiting step in the biosynthesis of all inositol-containing compounds. Homologous sequences are distributed across all kingdoms of life, but viruses. A two-reaction pathway is found for myo-inositol biosynthesis in all eukaryotic cells. First, glucose-6-phosphate is cyclized to form myo-inositol 1-phosphate, which is then dephosphorylated in the next step to produce free myo-inositol. These two steps are catalyzed by myo-inositol 1-phosphate synthase (EC 5.5.1.4) (IPS) and inositol monophosphatase (EC:3.1.3.25), respectively [Ref].  

    Ligand Summary



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