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The Open Protein Structure Annotation Network
PDB Keyword
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375214

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary

    Site JCSG
    Status Crystal Structure
    Target Id
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    Molecular Characteristics
    Source
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    Alias Ids TPS6843, Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS
    Ligand Information
    Ligands
    Metals
    Google Scholar output for

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    Protein Summary

    375214 is a puataive hydroxyethylthiazole kinase from Enterococcus faecalis V583. It shares significant sequence homology to hydroxyethylthiazole kinase protein from pyrococcus horikoshii OT3 (PDB 1v8a) and 4-methyl-5-beta-hydroxyethylthiazole kinase from bacillus subtilis (PDB 1c3q etc), and other TIM-fold enzymes as detected by FFAS (link) . The structure of 37514 is similar to  4-methyl-5-beta-hydroxyethylthiazole kinase  with rmsd of 1.53 A for 234 aligned Ca atoms (sequence idenitity 29%). The active site between these two enzymes are nearly identical, suggesting a conserved function. The asymmetric unit contains two monomers, the biological relevant trimers are generated by crystallographic symmetry (Figure 1).
     

    A member of HK family (PF02110).

    Figure 1: Trimer, ADP are shown in sticks.

    trimer.png

     

    Campobasso, N.,  Mathews, I.I.,  Begley, T.P.,  Ealick, S.E. (2000) Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution. Biochemistry 39: 7868-7877

    Ligand Summary

    Each promoter contains a ADP.

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    References

     

    No references found.

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    Files (1)

    FileSizeDateAttached by 
     trimer.png
    Trimer generated by crystallographic symmetry.
    196.34 kB00:19, 10 Jul 2008qxuActions
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