The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of putative class I ribonucleotide reductase (NP_241368.1) from Bacillus halodurans at 1.90 A resolution. To be published
    Site JCSG
    PDB Id 2rcc Target Id 377460
    Molecular Characteristics
    Source Bacillus halodurans c-125
    Alias Ids TPS1689,NP_241368.1, 1.20.1260.10 Molecular Weight 40239.49 Da.
    Residues 345 Isoelectric Point 4.94
    Sequence meqlqkrkiydttasnastgilngkssnvlnwddvrfswayplyknmlanfwtpfeinmshdakqfptl teteqeafkkiigllafldsvqtdysmraaeyltdsslaalmsvlsfqevvhnqsysyvlsslvpkatq deifeywkhddvlkernefiidgyekfvdnptpktflesivydvileglnfysgfaffynlarnqkmvs tstminyinrdeqlhvylftnifkellvefpelnteetktfvkttlmkaadlekdwfryiigdkipgin pedmetyisfiankravqlgmekpypeikhnpmkwirayedvnsgksdffeqksrqyakvsadngfdel
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.90 Rfree 0.215
    Matthews' coefficent 2.38 Rfactor 0.183
    Waters 340 Solvent Content 48.43

    Ligand Information


    Google Scholar output for 2rcc
    1. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
    2. Structure-Function Studies of the Large Subunit of Ribonucleotide Reductase from Homo sapiens and Saccharomyces cerevisiae
    JW Fairman - Doctoral Dissertations, 2009 - trace.tennessee.edu

    Protein Summary

    The gene NP_241368.1 from Bacillus halodurans encodes a ribonucleoside-diphosphate reductase  EC: (74% sequence identity with the homologous enzyme from Bacillus cellulosilyticusPF00268.  Alternative name: ribonucleotide reductase (RNR).  The enzyme belongs to the class of all  alpha proteins and adopts a ferritin-like fold type SCOP47240.  The enzyme catalyzes the following reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O <=> ribonucleoside diphosphate + thioredoxin.  This is the formation of deoxyribonucleotides from ribonucleotides.  The reaction catalyzed by RNR is strictly conserved in all living organisms.  RNR plays a critical role in regulating the total rate of DNA synthesis so that the ratio of DNA to cell mass is constant during cell division and DNA repair.

    Ligand Summary





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