The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of uncharacterized protein CHU_0679 (YP_677306.1) from Cytophaga hutchinsonii ATCC 33406 at 1.50 A resolution. To be published
    Site JCSG
    PDB Id 2qnl Target Id 376375
    Molecular Characteristics
    Source Cytophaga hutchinsonii atcc 33406
    Alias Ids TPS1675,YP_677306.1, 335855 Molecular Weight 18368.97 Da.
    Residues 161 Isoelectric Point 6.65
    Sequence mhtqealfvrlaldawntqssrtdkliqslsnealavetapgrnsgtyllghltavhdamlpllelgdt lypqlapvfiqnpdksglekpeindlrlywslvqerlanqfnqlqpadwfnkhaaisredflkephrnk lsvlinrtnhmayhlgqlaylkk
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.50 Rfree 0.185
    Matthews' coefficent 2.43 Rfactor 0.159
    Waters 250 Solvent Content 49.31

    Ligand Information


    Google Scholar output for 2qnl
    1. The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily
    DR Cooper, K Grelewska, CY Kim - Section F: Structural , 2010 - scripts.iucr.org

    Protein Summary

    The CHU_0679 gene codifies for the YP_677306.1 sequence that belongs to the DNA damage inducible (din) B group (PF05163). It shows the conserved catalytic triad (H52--//--H148---H152) involved in metal (Ni) chelation. Study of its genome context provides a very weak hit (score 0.46) with the DeoR family of transcriptional regulators (YP_677307).


    SCOP classifies 2qnl in the all-alpha class, DinB/YfiT-like putative metalloenzymes superfamily, DinB-like family. The highest structural similarity (FFAS scr=-21; Dali Z-scr=14) is observed with 3di5, a putative enzyme with Ni bound and coordinated by a conserved His triad  (H48, H127, H131). A second hit (HHpred P-val=1e-26; FATCAT P-val=1e-8) is with 1rxq, a putative metal dependent hydrolase member of the YfiT family crystallized with Ni bound to positions H67 and H164 together with two ordered water molecules [Ref].

    Ligand Summary





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