The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of uncharacterized protein AF2059 (2648472) from Archaeoglobus fulgidus at 1.95 A resolution. To be published
    Site JCSG
    PDB Id 2qg3 Target Id 355678
    Molecular Characteristics
    Source Archaeoglobus fulgidus dsm 4304
    Alias Ids TPS1348,2648472 Molecular Weight 22078.30 Da.
    Residues 196 Isoelectric Point 6.21
    Sequence mmweqfkkeklrgyleaknqrkvdfdivelldlinsfddfvtlsscsgriavvdlekpgdkasslflgk whegvevsevaeaalrsrkvawliqyppiihvacrnigaakllmnaantagfrrsgvislsnyvveias lerielpvaekglmlvddaylsyvvrwanekllkgkeklgrlqealeslqrenaycsd
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 1.95 Rfree 0.253
    Matthews' coefficent 2.02 Rfactor 0.199
    Waters 82 Solvent Content 39.01

    Ligand Information


    Google Scholar output for 2qg3
    1. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org

    Protein Summary

    The AF_2059 gene (PF02676, cl00689) from Archaeoglobus fulgidus DSM 4304 encodes the protein NP_070883 from the methyltransferase TYW3 family. The methyltransferase TYW3 has been found to be involved in wybutosine (yW) biosynthesis in eukaryotes like plants [Ref] and yeast [Ref]. Wybutosine is a largely modified guanosine residue found in the anticodon region of eukaryotic Phe-tRNA. Sequence homologs have also been found in archaea but not in bacteria.

    The 2qg3 structure belongs to the SCOP alpha+beta class, SSo0622-like (super)family. Dali identifies a PSI determined structure, 1tlj (Zscr=22) as significantly similar to 2qg3. Two other structures sharing more than 30% sequence identity have been determined outside PSI centers: 2drv (Z=25) and 2it2 (Z=24) from Pyrococcus hirokoshii.

    Ligand Summary





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