The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of uncharacterized protein SP_1565 (NP_346012.1) from Streptococcus pneumoniae TIGR4 at 2.00 A resolution. To be published
    Site JCSG
    PDB Id 2q7x Target Id 366227
    Molecular Characteristics
    Source Streptococcus pneumoniae tigr4
    Alias Ids TPS1473,NP_346012.1, PF01933, 283280 Molecular Weight 36031.32 Da.
    Residues 325 Isoelectric Point 5.54
    Sequence mrkpkitvigggtgspvilkslrekdveiaaivtvaddggssgelrknmqqltppgdlrnvlvamsdmp kfyekvfqyrfsedagafaghplgnliiaglsemqgstynamqllskffhttgkiypssdhpltlhavf qdgtevageshivdhrgiidnvyvtnalnddtplasrrvvqtilesdmivlgpgslftsilpnivikei gralletkaeiayvcnimtqrgetehftdsdhvevlhrhlgrpfidtvlvniekvpqeymnsnrfdeyl vqvehdfvglckqvsrvissnflrlenggafhdgdlivdelmriiqvkk
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.00 Rfree 0.236
    Matthews' coefficent 2.56 Rfactor 0.195
    Waters 282 Solvent Content 51.94

    Ligand Information


    Google Scholar output for 2q7x
    1. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
    2. New surface contacts formed upon reductive lysine methylation: Improving the probability of protein crystallization
    P Sledz, H Zheng, K Murzyn, M Chruszcz - Protein , 2010 - Wiley Online Library

    Protein Summary

    The SP_1565 gene from Streptococcus pneumoniae TIGR4 encodes for a protein, NP_346012, from the UPF0052 group (PF01933). Genome context analysis indicates a functional link (score 0.97) of SP_1565 with its genomic neighbor SP_1566, a UPF0042 nucleotide binding protein.

    2q7x structure adopts a mainly helical fold and belongs to the class of LPPG:Fo 2-phospho-L-lactate transferases (SCOP CofD-like family). 2q7x has considerable structural similarity (Dali Z=20) to chain A of 3c3d [Ref], corroborated by a significant hit in HHpred. Therefore, evidence is given that this protein structure is a putative 2-phospho-(L)-lactate transferase. A structural superposition of 2q7x and 3c3d shows conservation of the GDP binding site residues. Other similar structures (Z=34-28) determined by the PSI include 2o2z, 2hzb, 2ppv, and 2p0y. See the TOPSAN PF01933 groups page for details.

    Ligand Summary





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