The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Tellurite resistance protein of COG3793 (ZP_00109916.1) from Nostoc punctiforme PCC 73102 at 1.85 A resolution. To be published
    Site JCSG
    PDB Id 2ou3 Target Id 373118
    Molecular Characteristics
    Source Nostoc punctiforme pcc 73102
    Alias Ids TPS1618,NPUN_22DEC03_CONTIG1_REVISED_GENENPF6341, PF07049 Molecular Weight 18150.76 Da.
    Residues 160 Isoelectric Point 4.75
    Sequence msdikklgsswiinwffgfnqiptnedssiymksvltcakadgvispeekdwalgfcaswgvadwvied lktyeadealeeviarspqvsmaqrdillsaiwvsaadgelhekekakirkmatilgikeeivdqleql qqeeaalrqkrlnllypqkspy
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 1.85 Rfree 0.213
    Matthews' coefficent 2.22 Rfactor 0.161
    Waters 395 Solvent Content 44.66

    Ligand Information


    Google Scholar output for 2ou3
    1. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
    2. Ligands in PSI structures
    A Kumar, HJ Chiu, HL Axelrod, A Morse - Section F: Structural , 2010 - scripts.iucr.org

    Protein Summary

    The gene Npun_F6341 translates into the amino acid sequence YP_001869556 corresponding to a hypothetical protein that belongs to the Tellurite resistance protein B-like group (PF05099), with more than 650 bacterial representatives with the same domain architecture. Its HMM profile shows a highly conserved sequence pattern: D37-E44--D110-E117. The structure solved here, 2ou3, shows a Zn ion chelated by the equivalent residues: D42-E49--D107-E114.

    SCOP classifies 2ou3 as belonging to the all-alpha class, TerB-like superfamily, COG3793-like family. HHpred and FFAS provide hits with the TerB-like proteins 2jxu (Pval=2.1e-23; score=-36.8) and 2h5n (Pval=1.6e-9; score=-15.2). Structural comparison servers consistently selected 2h5n as top hit: SSM sse=63%; Dali Z-scr=7.6; FATCAT P-val=6.5e-6.

    For a recent overview on tellurium oxianions and associated bacterial resistance, including tellurite (TeO32-), see [Ref].

    Ligand Summary





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