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The Open Protein Structure Annotation Network
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2ka7

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title The J-UNIO protocol for automated protein structure determination by NMR in solution. To be Published
    Site JCSG
    PDB Id 2ka7 Target Id
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    Related PDB Ids 1zko 
    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1191,TM0212, 84858
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method NMR
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    Chains 1

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2ka7
    1. The J-UNIO protocol for automated protein structure determination by NMR in solution
    P Serrano, B Pedrini, B Mohanty, M Geralt - Journal of biomolecular , 2012 - Springer
     

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    Protein Summary


    The TM0212 gene from Thermotoga maritima codes for the glycine cleavage system H protein  (NP_228027; EC classification: EC:1.4.4.2; ortholog gene cluster COG0509).  

    SCOP classifies 2ka7 inside the all beta class, single hybrid motif superfamily, biotinyl/lipoyl-carrier protein family. 2ka7 is the solution structure PDB code for the 1.65A resolution crystal structure deposited as (1ZKO). Using 2ka7/1zko as query, Dali top hits with Z-scr=23 are with glycine cleavage system H proteins 1onl, 3a7l and 1hpc.

     

    The protein belongs to the biotinyl-lipoyl domain superfamily PF01597.  This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyses the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue (Lys 60 in 2ka7). The H protein shuttles the methylamine group of glycine from the P protein to the T protein [Ref].

    Ligand Summary



    References

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    References

     

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