The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of cysteine dioxygenase type I (YP_299237.1) from Ralstonia eutropha JMP134 at 1.84 A resolution. To be published
    Site JCSG
    PDB Id 2gm6 Target Id 361076
    Molecular Characteristics
    Source Ralstonia eutropha jmp134
    Alias Ids TPS1461,YP_299237.1,, PF05995, 90681 Molecular Weight 22780.28 Da.
    Residues 207 Isoelectric Point 5.82
    Sequence msesptagraslaplrefitglsalldeqpgearilreggallarlvarddwlpdafaqphpeyyqqml lhcdsaerfsivsfvwgpgqrtpihdhtvwgligmlrgaeysqpfvldgsgrpvlhgeptrlepghvea vsptvgdihrvhnayddrvsisihvyganiggvrrsvyteagerkpfisgysnpylpnpwdrskdsaas
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.84 Rfree 0.207
    Matthews' coefficent 3.55 Rfactor 0.18
    Waters 213 Solvent Content 65.12

    Ligand Information


    Google Scholar output for 2gm6
    1. An insight into the mechanism of human cysteine dioxygenase
    S Ye, X Wu, L Wei, D Tang, P Sun, M Bartlam - Journal of Biological , 2007 - ASBMB
    2. Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria
    JE Dominy Jr, CR Simmons, PA Karplus - Journal of , 2006 - Am Soc Microbiol
    3. Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity
    JE Dominy Jr, J Hwang, S Guo, LL Hirschberger - Journal of Biological , 2008 - ASBMB
    4. Cysteine dioxygenase: structure and mechanism
    CA Joseph, MJ Maroney - Chem. Commun., 2007 - xlink.rsc.org
    5. Thiol dioxygenases: unique families of cupin proteins
    MH Stipanuk, CR Simmons, P Andrew Karplus - Amino Acids, 2011 - Springer
    6. Structure and Function of Atypically Coordinated Enzymatic Mononuclear Non-heme-Fe (II) Centers
    D Buongiorno, G Straganz - Coordination Chemistry Reviews, 2012 - Elsevier
    7. Cysteine Dioxygenase: The Importance of Key Residues and Insight into the Mechanism of the Metal Center
    JH Leung - Masters Theses, 2008 - scholarworks.umass.edu

    Protein Summary

    The Reut_B5045 (YP_299237.1) gene from Ralstonia eutropha encodes the enzyme cysteine dioxygenase type I PF05995 EC:  The enzyme contains cupin-like domain RmlC SCOP51182.  The enzyme catalyzes the following reaction: L-cysteine + O(2) <=> 3-sulfinoalanine.  This reaction is a branch-point in cysteine catabolism, where it can follow two pathways resulting in the formation of taurine or sulfate.  3-sulfinoalanine-dependent pathway of taurine metabolism follows the synthesis of hypotaurine (2-aminoethane sulfinate), which is subsequently oxidized to taurine.

    Ligand Summary





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