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The Open Protein Structure Annotation Network
PDB Keyword
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2gb4

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution. To be published
    Site JCSG
    PDB Id 2gb4 Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1334,18204406, 89641, 89682, 89713, 289628, 289423, 289446, 289625, 289339
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 2
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.43 Rfactor
    Waters
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    Solvent Content 48.98

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2gb4
    1. Structural Basis of Substrate Recognition in Thiopurine S-Methyltransferase
    Y Peng, Q Feng, D Wilk, AA Adjei - Biochemistry, 2008 - ACS Publications
     

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    Protein Summary

    The gene 18204406 from Mus musculus (mouse) encodes the enzyme thiopurine S-methyltransferase (TPMT) EC:2.1.1.67 PF05724.  The enzyme catalyzes methylation of thiopurine compounds. The methyl is transferred from S-adenosyl-L-methionine, which is converted to S-adenosyl-L-homocysteine.  The protein contains the Rossman-fold NAD(P)-binding domain.  To date several crystal structures of the enzyme  and its homologues have been solved (PDB:3BGD3BGI, 2BZG).  The enzyme attracts significant attention because of its involvement in modulating cytotoxic effects of such prodrugs as 6-mercaptopurine.  6-mercaptopurine is a chemotherapeutic agent.   Patients with TPMT variant allozymes exhibit diminished levels of protein and/or enzyme activity and are at risk for thiopurine drug-induced toxicity [Ref].

    Ligand Summary



    References

    Reviews

    References

     

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