The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Endoglucanase (tm1049) from THERMOTOGA MARITIMA at 2.01 A resolution. To be published
    Site JCSG
    PDB Id 2fvg Target Id 282916
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1256,TM1049, 3.40.630.10, 289531, 90008 Molecular Weight 37326.64 Da.
    Residues 339 Isoelectric Point 6.05
    Sequence mylkelsmmpgvsgdegkvrdfikskieglvdnlytdvlgnlialkrgrdsskkllvsahmdevgfvvs kiekdgkvsflpvggvdprilpgkvvqvknlkgvigyrpihlqrdeentpprfenlridfgfssadeak kyvsigdyvsfvsdyiekngravgkafddragcsvlidvlesgvspaydtyfvftvqeetglrgsavvv eqlkptcaivvetttagdnpeleerkwathlgdgpaitfyhrgyvipkeifqtivdtaknndipfqmkr rtaggtdagryartaygvpagvistparyihspnsiidlndyentkklikvlveegkivevvs
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 2.01 Rfree 0.24423
    Matthews' coefficent 2.26 Rfactor 0.20277
    Waters 114 Solvent Content 45.46

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    Ligand Information


    Google Scholar output for 2fvg
    1. Research Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution
    MV Omelchenko, MY Galperin, YI Wolf, EV Koonin - 2010 - biomedcentral.com

    Protein Summary

    The TM1049 gene from Thermotoga maritima encodes an endoglucanase E.C. COG3405 PF05343.  The enzyme belongs to a family of FrvX endoglucanases (cellulase M and related proteins).  The enzyme catalyzes the hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, lichenin and cereal beta-D-glucans.  In the case of cellulose, the enzyme complex breaks down cellulose to beta-glucose. This type of cellulase is produced mainly by symbiotic bacteria in the ruminating chambers of herbivores.

    Ligand Summary





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