The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of (np_880937.1) from BORDETELLA PERTUSSIS at 1.80 A resolution. To be published
    Site JCSG
    PDB Id 2fqp Target Id 359159
    Molecular Characteristics
    Source Bordetella pertussis tohama i
    Alias Ids TPS1420,NP_880937.1,, 85229 Molecular Weight 10717.63 Da.
    Residues 96 Isoelectric Point 5.27
    Sequence mkrpgaiptvqidnervkvtewrfppggetgwhrhsmdyvvvpmttgpllletpegsvtsqltrgvsyt rpegvehnvinpsdtefvfveieikaa
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 4
    Resolution (Å) 1.80 Rfree 0.202
    Matthews' coefficent 1.83 Rfactor 0.154
    Waters 278 Solvent Content 36.47

    Ligand Information


    Google Scholar output for 2fqp
    1. Homology modeling and function prediction of hABH1, involving in repair of alkylation damaged DNA
    S Das, AS Vidyarthi - Interdisciplinary Sciences: Computational Life , 2011 - Springer

    Protein Summary

    The gene BP2299 from Bordetella pertussis encodes a putative cupin domain PF07883. Analysis of its genome neighborhood shows the presence of the BP2298 protein, an aminobutyrate aminotransferase (score 0.75).

    The protein structure, 2fqp, belongs to the class of all beta proteins, and reveals double-stranded beta-helix fold type, from the RmlC-like cupins superfamily SCOP51181.  A DALI search returns as top hits the RPA4178 protein  PDB:3lag and PDB:2ozi (Z=18), the cupin TM1459 PDB:1vj2 (Z=11), and a putative sugar phosphate isomerase PDB:3l2h (Z=10). Many other cupin-like domain structures have been solved from different organisms like the Bacillus subtilis YxaG protein PDB:1y3t (Z=7.5). Each 2fqp chain chelates a Zn ion via the conserved triad H33, H35 and H76.

    The cupin domain is found in one or two copies in   proteins whose  functions  vary  from  isomerase  and epimerase activities involved in  the  modification of  cell  wall  carbohydrates  in bacteria, to  non-enzymatic storage proteins in plant seeds, and transcription factors linked  to  congenital  baldness  in mammals.  

    Ligand Summary





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