The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of (2649480) from ARCHAEOGLOBUS FULGIDUS at 2.45 A resolution. To be published
    Site JCSG
    PDB Id 2ffj Target Id 360250
    Molecular Characteristics
    Source Archaeoglobus fulgidus dsm 4304
    Alias Ids TPS1445,NP_069933.1 Molecular Weight 31979.06 Da.
    Residues 288 Isoelectric Point 5.09
    Sequence mkisplcpscllgrvyyeaklvtddedlisqcvdeslkilaenyssrpinahlatrihrrvyeilgved pyaevkaranevarqvlplakeivegsddpfktavivsivgnnfdygvqghkvveeefrdflkrkvqeg lkindterikelssgkvvyltdnageiffdtllmkeikrrcekltavvrgrpiisdatiedarlarvdk iadelltngkgaigiimdelpdetrkaleeadlivakgmanyeclsdgslkpiaflltakcepvardig vnvgdmvakvve
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 2
    Resolution (Å) 2.45 Rfree 0.255
    Matthews' coefficent 2.48 Rfactor 0.189
    Waters 89 Solvent Content 50.46

    Ligand Information


    Google Scholar output for 2ffj

    Protein Summary

    The AF1104 (NP_069933.1) gene from Archaeoglobus fulgidus encodes a protein of unknown function DUF89 PF01937.  The protein belongs to the class of multi-domain proteins (alpha and beta) and reveals AF1104-like fold type SCOP111320.  The structure of the protein contains two well-defined domain.  The C-terminal domain is an all-alpha 3-helical bundle, which is similar to  the immunoglobulin/albumin-binding domain-like fold SCOP46996.  The N-terminal domain in general looks similar in structure to the subunit of bacterial pilin family of proteins, although orientation of beta-sheets does not match 3JYZ.  Pilin is a component of pili.  Pili connect a bacterium to another of its species, or to another bacterium of a different species, and build a bridge between the interior of the cells. This enables the transfer of plasmids between the bacteria.


    Human homolog (Q9NVE7) is annotated as pantothenate kinase 4 (EC as are other eukaryotic homologs, e.g. Q8L5Y9 in Arabidopsis thaliana and in Drosophila melanogaster. It has a lenght of more than 700 residues where from 35 to 370 resides the ROK kinase domain followed by the DUF89 (residues 450-760).


    DUF89 is fused with Fumble domain (PF03630) in 38 homologs (Pfam entries), putative phosphatase domain (PF06888) in 5 entries and other phosphatases (PF00316, PF00149) in 4 entries.

    Ligand Summary





    No references found.

    Tag page

    Files (0)

    You must login to post a comment.
    All content on this site is licensed under a Creative Commons Attribution 3.0 License
    Powered by MindTouch