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The Open Protein Structure Annotation Network
PDB Keyword
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2f8j

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transferase) (tm1040) from Thermotoga maritima at 2.40 A resolution. To be published
    Site JCSG
    PDB Id 2f8j Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1436,TM1040, 3.40.640.10, 396399
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.40 Rfactor 0.182
    Waters
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    Solvent Content 48.32

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2f8j
    1. Microbial drug target identification using different computational approaches: Specific application to Pseudomonas aeruginosa
    D Perumal, CS Lim - Innovations in Information , 2008 - ieeexplore.ieee.org
     

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    Protein Summary

    The gene TM1040 from Thermotoga maritima encodes an enzyme histidinol-phosphate aminotransferase (HspAT), a member of aminotransferase class I and II family PF00155.  The enzyme belongs to the class of alpha and beta (a+b) proteins and reveals Pyridoxal 5′-phosphate (PLP)-dependent transferase-like fold type SCOP53382. In histidine biosynthesis, histidinol-phosphate aminotransferase catalyzes the transfer of the amino group from glutamate to imidazole acetol-phosphate producing 2-oxoglutarate and histidinol phosphate.  The structure of this enzyme from the same organism has been determined previously 1H1C. HspAT exists as a dimer.

    Ligand Summary

    Pyridoxal 5′-phosphate (PLP) is a cofactor for HspAT. PLP is covalently bound to Lys202 and accepts the amino group from L-glutamate to form the intermediate species pyridoxamine 5′-phosphate (PMP). HspAT can be purified as a mixture of PLP and PMP complex. Both forms are present in at least one copy of the active site, PMP being dominant in the other three.

    References

    Reviews

    References

     

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