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The Open Protein Structure Annotation Network
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2f4l

    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Acetamidase, putative (tm0119) from THERMOTOGA MARITIMA at 2.50 A resolution. To be published
    Site JCSG
    PDB Id 2f4l Target Id
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    Molecular Characteristics
    Source
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    Alias Ids
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    TPS1183,TM0119, PF03069, 89973, 90124
    Molecular Weight
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    Da.
    Residues
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    Isoelectric Point
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    Sequence
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      BLAST   FFAS

    Structure Determination
    Method XRAY
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    Chains 4
    Resolution (Å)
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    Rfree
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    Matthews' coefficent 2.44 Rfactor 0.192
    Waters
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    Solvent Content 54.16

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    Ligand Information
    Ligands
    Metals

    Jmol

     
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    Google Scholar output for 2f4l
    1. Zinc through the three domains of life
    C Andreini, L Banci, I Bertini - Journal of proteome , 2006 - ACS Publications
     
    2. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
     
    3. On the combination of molecular replacement and single-wavelength anomalous diffraction phasing for automated structure determination
    S Panjikar, V Parthasarathy, VS Lamzin - Section D: Biological , 2009 - scripts.iucr.org
     
    4. Re-Annotation of Two Hyperthermophilic Archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638
    J Gao, J Wang - Current microbiology, 2012 - Springer
     
    5. Crystal Structure Analysis of a Recombinant Predicted Acetamidase/Formamidase from the Thermophile Thermoanaerobacter tengcongensis
    M Qian, Q Huang, G Wu, L Lai, Y Tang, J Pei - The Protein , 2012 - Springer
     

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    Protein Summary

    TM0119 gene from Thermotoga maritima encodes the protein NP_227935, a putative acetamidase (similar to proteins from COG2421). TM0119 shows a tandem repetition (1-140; 140-280) of the PF03069 group sequence that contains amidohydrolases of formamide (EC:3.5.1.49) and acetamide. Its neighboring gene, TM0120, is annotated as putative oxidoreductase.


    SCOP classifies 2f4l in the all beta class, acetamidase/formamidase-like (super)family. 2f4l top Dali hits are with

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    (Z-scr=41), and
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    (Z-scr=34). The N-terminal domain is a jelly-roll made of two greek-key motifs and is most commonly seen in viral capsid proteins. It contains extensive insertions to the jelly-roll core. It is difficult to determine if the insert region (76-120) should be classified as a separate domain. The C-terminal is a small domain with structural similarity to the SCOP fold: probable bacterial effector-binding domain (link).

    An industrially attractive L-specific amidase belongs to the same protein family ([Ref]) indicating that TM0119 may have substrate specificity for the L-enantiomers.

    Ligand Summary



    References

    Reviews

    References

     

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