The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of LEMA protein (tm0961) from THERMOTOGA MARITIMA at 2.28 A resolution. To be published
    Site JCSG
    PDB Id 2etd Target Id 358514
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1396,TM0961, PF04011 Molecular Weight 17917.38 Da.
    Residues 159 Isoelectric Point 5.41
    Sequence lvsleqevqekysqiqnqlqrradlipnlvetvkgyaahekeileeianarakligaktpqesaqadae lssalsrllaiaenypnlkadanfrqlmdelagtenriavarrdyneavkkyntaikkfpgvifakmfg feekqyfeakpgaeevpevkf
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 2.28 Rfree 0.27
    Matthews' coefficent 2.29 Rfactor 0.216
    Waters 62 Solvent Content 46.39

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    Ligand Information


    Google Scholar output for 2etd
    1. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
    2. Automatic procedure for using models of proteins in molecular replacement
    D Raimondo, A Giorgetti, S Bosi - PROTEINS: Structure, , 2007 - Wiley Online Library
    3. Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634
    CJ McCleverty, L Columbus, A Kreusch - Protein , 2008 - Wiley Online Library

    Protein Summary

    The gene TM0961 from Thermotoga maritima encodes a predicted transmembrane protein (NP_228769) from the LemA family PF04011.

    SCOP classifies 2etd in the all alpha class, bromodomain-like fold, LemA-like (super)family. DALI weak hits are with the huntingtin interacting protein-12 PDB:1r0d (Z=9), pectin methylesterase inhibitor PDB:1x90 (Z=9) and the uncharacterized XCC0516 protein PDB:2gsc (Z=9).

    The protein is highly conserved among different bacterial species.  The LemA protein family performs regulatory functions. In the context of bacterial intracellular pathogens, they modulate guest-host relationships.  For example, the LemA gene is required for pathogenicity of Pseudomonas syringae on bean [Ref].  The LemA proteins contain a transmembrane domain and an N-terminal extracellular domain.  The exposed N-terminal domain of the LemA protein is the major antigen for recognition by the immune system of the infected multicellular organism [Ref].    

    Ligand Summary





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