The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of hypothetical protein (tm0922) from THERMOTOGA MARITIMA at 2.27 A resolution. To be published
    Site JCSG
    PDB Id 2ax3 Target Id 282791
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1246,TM0922, 3.40.1190.20, 429684, 452243 Molecular Weight 53001.37 Da.
    Residues 490 Isoelectric Point 5.72
    Sequence mkeideltikeygvdsrilmeragisvvlameeelgnlsdyrflvlcgggnnggdgfvvarnllgvvkd vlvvflgkkktpdceynyglykkfggkvveqfepsilnefdvvvdaifgtglrgeitgeyaeiinlvnk sgkvvvsvdvpsgidsntgkvlrtavkadltvtfgvpkighilfpgrdltgklkvanighpvhlinsin ryvitremvrsllperprdshkgtygkvliiagsrlysgapvlsgmgslkvgtglvklavpfpqnliat srfpelisvpidtekgffslqnlqeclelskdvdvvaigpglgnnehvrefvneflktlekpavidada invldtsvlkerkspavltphpgemarlvkktvgdvkynyelaeefakendcvlvlksattivtdgekt lfnitgntglskggsgdvltgmiagfiaqglspleastvsvylhgfaaelfeqdergltasellrlipe airrlke
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 2.27 Rfree 0.218
    Matthews' coefficent 2.60 Rfactor 0.159
    Waters 172 Solvent Content 52.29

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    Ligand Information


    Google Scholar output for 2ax3
    1. Decision-making in structure solution using Bayesian estimates of map quality: the PHENIX AutoSol wizard
    TC Terwilliger, PD Adams, RJ Read - Section D: Biological , 2009 - scripts.iucr.org
    2. Crystal structure of human Edc3 and its functional implications
    SHM Ling, CJ Decker, MA Walsh, M She - and cellular biology, 2008 - Am Soc Microbiol
    3. Biochemical and structural characterization of apolipoprotein AI binding protein, a novel phosphoprotein with a potential role in sperm capacitation
    KN Jha, IA Shumilin, LC Digilio, O Chertihin - Endocrinology, 2008 - Endocrine Soc
    4. Autoindexing with outlier rejection and identification of superimposed lattices
    NK Sauter, BK Poon - Journal of Applied Crystallography, 2010 - scripts.iucr.org
    5. Preliminary X-ray crystallographic analysis of SMU. 573, a putative sugar kinase from Streptococcus mutans
    YF Zhou, LF Li, C Yang, YH Liang - Crystallographica Section F , 2007 - scripts.iucr.org
    6. Re-Annotation of Two Hyperthermophilic Archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638
    J Gao, J Wang - Current microbiology, 2012 - Springer
    7. Identification of Unknown Protein Function Using Metabolite Cocktail Screening
    IA Shumilin, M Cymborowski, O Chertihin, KN Jha - Structure, 2012 - Elsevier
    8. Protein secondary structure predict based on the path with the maximum weight
    L Luo, Z Shao - Computing and Intelligent Systems, 2009. ICIS , 2009 - ieeexplore.ieee.org

    Protein Summary

    The gene TM0922 from Thermotoga maritima encodes a protein of unknown function.  The structure contains 2 clearly defined domains.  The N-terminal domain is related to YJEF superfamily domain PF03853.  The YjeF N-terminal domain occurs either as single proteins or fusions with other domains.  YJEF domains are commonly associated with enzymes. In bacteria and archaea, YjeF N-terminal domains are often fused to C-terminal domain with high structural homology to the members of a ribokinase-like superfamily.  The C-terminal domain of the TM0922 gene can be generally characterized as a sugar kinase domain PF01256, most probably involved in carbohydrate transport and metabolism.  This family is related to hydroxyethylthiazole and PfkB carbohydrate kinases. 

    Dali provides hits with the carbohydrate kinase 3k5w (Z=40), the YJEF related protein 2r3b (Z=35), the apolipoprotein binding 2o8n (Z=25), and the hydroxyehtylthiazole kinase 1v8a (Z=23).

    Ligand Summary





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