The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of (np_812058.1) from BACTEROIDES THETAIOTAOMICRON VPI-5482 at 2.16 A resolution. To be published
    Site JCSG
    PDB Id 2a2o Target Id 358760
    Related PDB Ids 2a2m 
    Molecular Characteristics
    Source Bacteroides thetaiotaomicron vpi-5482
    Alias Ids TPS1404,NP_812058.1, 282926 Molecular Weight 28144.14 Da.
    Residues 246 Isoelectric Point 4.86
    Sequence mndfknqwlrkrtfaipasrltgrlttlksdvpaadslfwklwngsldtavqvlqtdyfkgiaagtldp naygslmvqdgyycfrgrddyataatcaqdetlreffkakaksydeynetyhqtwhlreasglipgtdi kdyadyeayvagslaspymcvvmlpceylwpwianfldgytptnslyrfwiewnggtpngayqmgnmle qyrdkidedkaveifntamnyelkvftsstilttiengk
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 7
    Resolution (Å) 2.16 Rfree 0.173
    Matthews' coefficent 4.08 Rfactor 0.145
    Waters 1715 Solvent Content 69.64

    Ligand Information


    Google Scholar output for 2a2o
    1. Kinetic modelling in systems biology
    O Demin, I Goryanin - 2009 - books.google.com

    Protein Summary

    The gene BT_3146 from Bacteroides thetaiotaomicron encodes the NP_812058 protein, a putative transcriptional activator TenA homologue (PF03070).

    SCOP classifies 2a2o in the all alpha class, heme oxygenase-like superfamily, TenA/THI-4 family. Using 2a2o as query, Dali top hits are with TenA proteins like 2gm8 and 1udd (Z=24). 2a2o is very similar structurally to the homologous protein from Pyrococcus horikoshii 2RD3 (Dali Zscr=24).  The latter protein, in turn, is homologous to the Bacillus subtilis TenA-homologue protein PH1161.  

    TenA is known to belong to a family of transcription activators that stimulate the production of extracellular proteases in B. subtilis [Ref].

    Ligand Summary





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