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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of ABC transporter ATP-binding protein (TM0544) from Thermotoga maritima at 2.10 A resolution. To be published
    Site JCSG
    PDB Id 1vpl Target Id 282417
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1212,TM0544, _0000.000321_, _0000.000166_, BV1071, _0000.000765_, 289579 Molecular Weight 27128.00 Da.
    Residues 244 Isoelectric Point 5.83
    Sequence mgavvvkdlrkrigkkeilkgisfeieegeifgligpngagktttlriistlikpssgivtvfgknvve ephevrklisylpeeagayrnmqgieylrfvagfyasssseieemverateiaglgekikdrvstyskg mvrklliaralmvnprlaildeptsgldvlnarevrkilkqasqegltilvsshnmleveflcdriali hngtivetgtveelkerykaqnieevfeevvkcsenf
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 2.10 Rfree 0.21581
    Matthews' coefficent 2.98 Rfactor 0.17139
    Waters 137 Solvent Content 58.46

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    Ligand Information


    Google Scholar output for 1vpl
    1. A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression
    HM Knight, BS Pickard, A Maclean, MP Malloy - The American Journal of , 2009 - Elsevier
    2. The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration
    RS Molday, M Zhong, F Quazi - et Biophysica Acta (BBA)-Molecular and , 2009 - Elsevier
    3. Building an understanding of cystic fibrosis on the foundation of ABC transporter structures
    JL Mendoza, PJ Thomas - Journal of bioenergetics and biomembranes, 2007 - Springer
    4. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches
    R Schwarzenbacher, A Godzik - Section D: Biological , 2007 - scripts.iucr.org
    5. Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study
    RM Rutledge, L Esser, J Ma, D Xia - Journal of structural biology, 2011 - Elsevier
    6. Functional significance of the E loop, a novel motif conserved in the lantibiotic immunity ATP-binding cassette transport systems
    K Okuda, S Yanagihara, T Sugayama - Journal of , 2010 - Am Soc Microbiol
    7. Identification of putative steroid-binding sites in human ABCB1 and ABCG2
    S Mares-Smano, R Badhan, J Penny - European journal of medicinal , 2009 - Elsevier

    Protein Summary

    The TM0544 gene from Thermotoga maritima encodes an ABC transporter (PF00005, COG1131, EC The TM0544 structure adopts a P-loop containing nucleoside triphosphate hydrolase fold and shows strong structural similarity with from Aquifex aeolicus (PDB ids: 2pcl, 2pcj). Similar results were obtained for ATP-binding cassettes from Methanococcus jannaschii (PDB id: 1f3o) and Geobacillus stearothermophilus (PDB id: 2ouk). See Yuan 2001 and Vahedi-Faridi 2008  for more details on structure and function.


    Ligand Summary





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