The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of hypothetical protein (TM0723) from Thermotoga maritima at 1.52 A resolution. To be published
    Site JCSG
    PDB Id 1vmj Target Id 282593
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1228,TM0723, 84688 Molecular Weight 16327.95 Da.
    Residues 139 Isoelectric Point 6.08
    Sequence mksyrkelwfhtkrrrefinitplleecvresgikeglllcnamhitasvfinddepglhhdfevwlek lapekpysqykhndtgednadahlkrtimgrevviaitdrkmdlgpweqvfygefdgmrpkrvlvkiige
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 1.52 Rfree 0.16302
    Matthews' coefficent 2.85 Rfactor 0.144
    Waters 213 Solvent Content 56.48

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    Ligand Information


    Google Scholar output for 1vmj
    1. Sensitive genome-wide screen for low secondary enzymatic activities: the YjbQ family shows thiamin phosphate synthase activity
    E Morett, G Saab-Rincn, L Olvera, M Olvera - Journal of molecular , 2008 - Elsevier
    2. Ligands in PSI structures
    A Kumar, HJ Chiu, HL Axelrod, A Morse - Section F: Structural , 2010 - scripts.iucr.org
    3. Crystal structure of the hypothetical protein ST2072 from Sulfolobus tokodaii
    Y Tanaka, K Tsumoto, E Tanabe - Proteins: Structure, , 2005 - Wiley Online Library

    Protein Summary

    The TM0723 gene of Thermotoga maritima encodes a protein of uncharacterized function (PF01894, COG0432). The family shows a wide species distribution with over 500 sequences in over 400 species including eukaryotes (sea anemone, fruit fly, mosquito, tapeworm, fungi, rice and yeast), prokaryotes (actinobacteria, bacteroidetes, chloroflexi and firmicutes) and archaea. A number of other structures solved as part of the worldwide Structural Genomics initiative display strong structural (main-chain rmsd between 0.6-1.8 Å over 118-139 residues) and sequence similarity (sequence identity 31-60%) with TM0723 including 2p6c, 1vph, 2p6h, 1xbf, 1vmf and 2cu5. Pre-SCOP describes the structure as adopting a novel fold termed YjbQ-like.


    The protein architecture of another family homolog from smut fungus (Q4PFT5_USTMA) contains PX (PF00787), PH (PF00169) and RhoGAP (PF00620) domains, suggesting a function in signal transduction implicating the cytoskeleton.


    Thiamin phosphate synthase activity has been shown [Ref], however this is probably not the primary function of this family.


    [check Drosophila, yeast knock-outs/screens]

    Genetic neighborhood:

    TM0723: ribonuclease R, UMP pyrophosphorylase, serine hydroxylmethyltransferase, purine-binding chemotaxis protein, ComM protein (predicted ATPase with chaperone activity)


    PH0581: alanyl tRNA synthetase, dimethyladenosine transferase, translation termination factor

    Ligand Summary





    1. (No Results)


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