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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Ferritin (TM1128) from Thermotoga maritima at 2.00 A resolution. To be published
    Site JCSG
    PDB Id 1vlg Target Id 282994
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1263,TM1128, 1.20.1260.10, 84767 Molecular Weight 19377.93 Da.
    Residues 164 Isoelectric Point 4.84
    Sequence mmvisekvrkalndqlnreiyssylylsmatyfdaegfkgfahwmkkqaqeelthamkfyeyiyerggr veleaiekppsnwngikdafeaalkheefvtqsiynilelaseekdhatvsflkwfvdeqveeedqvre ildllekangqmsvifqldrylgqre
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 8
    Resolution (Å) 2.00 Rfree 0.218
    Matthews' coefficent 3.20 Rfactor 0.178
    Waters 651 Solvent Content 61.28

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    Ligand Information


    Google Scholar output for 1vlg
    1. Crystal structure of the ferritin from the hyperthermophilic archaeal anaerobe Pyrococcus furiosus
    J Tatur, WR Hagen, PM Matias - Journal of Biological Inorganic Chemistry, 2007 - Springer
    2. The JCSG MR pipeline: optimized alignments, multiple models and parallel searches
    R Schwarzenbacher, A Godzik - Section D: Biological , 2007 - scripts.iucr.org
    3. Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins
    R Page, AM Deacon, SA Lesley - Journal of structural and , 2005 - Springer
    4. Crystallization and preliminary X-ray characterization of a ferritin from the hyperthermophilic archaeon and anaerobe Pyrococcus furiosus
    PM Matias, J Tatur, MA Carrondo - Section F: Structural , 2005 - scripts.iucr.org
    5. Symerythrin structures at atomic resolution and the origins of rubrerythrins and the ferritin-like superfamily
    RB Cooley, DJ Arp, PA Karplus - Journal of Molecular Biology, 2011 - Elsevier
    6. The characterization of Thermotoga maritima ferritin reveals an unusual subunit dissociation behavior and efficient DNA protection from iron-mediated oxidative stress
    P Ceci, E Forte, G Di Cecca, M Fornara, E Chiancone - Extremophiles, 2011 - Springer
    7. Ferritin Structure from Mycobacterium tuberculosis: Comparative Study with Homologues Identifies Extended C-Terminus Involved in Ferroxidase Activity
    G Khare, V Gupta, P Nangpal, RK Gupta, NK Sauter - PloS one, 2011 - dx.plos.org
    8. Crystallization and preliminary X-ray crystallographic analysis of a Mycobacterium tuberculosis ferritin homolog, BfrB
    LM McMath, JE Habel, B Sankaran, M Yu - Section F: Structural , 2010 - scripts.iucr.org

    Protein Summary

    The TM1128 gene from Thermotoga maritima encodes a non-heme ferritin COG1528 from ferritin-like superfamilies DPS and bacterioferritins PF00210.  The structure of this protein has been previously solved 1Z4A.  Non-heme ferritin domain, found in Archaea and Bacteria, is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The ferritin protein shell is usually composed of 24 protein subunits arranged in 432 symmetry. Each protein subunit, a four-helix bundle with a fifth short terminal helix, contains a dinuclear ferroxidase center (H type). Unique to this group of proteins is a third metal site in the ferroxidase center. Iron storage involves the uptake of iron (II) at the protein shell, its oxidation by molecular oxygen at the ferroxidase centers, and the movement of iron (III) into the cavity for deposition as ferrihydrite.  The multi-subunit protein shell, that encloses ferrihydrite,  assures its solubility in an aqueous environment.  

    Ligand Summary





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