The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of Uracil phosphoribosyltransferase (TM0721) from Thermotoga maritima at 2.30 A resolution. To be published
    Site JCSG
    PDB Id 1o5o Target Id 282591
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1227,TM0721, 85035 Molecular Weight 23318.98 Da.
    Residues 209 Isoelectric Point 5.62
    Sequence mknlvvvdhplikhkltimrdkntgpkefrellreitlllayeatrhlkceevevetpitktigyrind kdivvvpilraglvmadgilellpnasvghigiyrdpetlqaveyyaklpplnddkevflldpmlatgv ssikaieilkengakkitlvaliaapegveavekkyedvkiyvaalderlndhgyiipglgdagdrlfrtk
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 4
    Resolution (Å) 2.30 Rfree 0.23635
    Matthews' coefficent 2.44 Rfactor 0.16658
    Waters 355 Solvent Content 49.20

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    Ligand Information


    Google Scholar output for 1o5o
    1. The importance of alignment accuracy for molecular replacement
    R Schwarzenbacher, A Godzik - Section D: Biological , 2004 - scripts.iucr.org
    2. Shotgun crystallization strategy for structural genomics II: crystallization conditions that produce high resolution structures for T. maritima proteins
    R Page, AM Deacon, SA Lesley - Journal of structural and , 2005 - Springer
    3. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target
    KA Kantardjieff, C Vasquez, P Castro - Section D: Biological , 2005 - scripts.iucr.org
    4. Pyrimidine Salvage Pathway in Mycobacterium tuberculosis
    AD Villela, ZA Sanchez-Quitian - Current Medicinal , 2011 - ingentaconnect.com
    5. Three zone segregation of proteins-a comparison of structures
    R Sinha - Potentials, IEEE, 2006 - ieeexplore.ieee.org

    Protein Summary

    The TM0721 gene from Thermotoga maritima encodes an uracil phosphoribosyltransferase (PF00156, COG0035, EC The TM0721 structure adopts a phosphoribosyl-transferase-like fold and shows strong structural similarity with the homolog from another hyperthormophile, Thermus thermophilus (PDB id: 1v9s) with a main-chain rmsd of 1.0 Å over 206 residues and a sequence identity of 57%. Similar results were obtained with homologs from Escherichia coli (PDB id: 2ehj), Aquifex aeolicus (PDB id: 2e55), Burkholderia pseudomallei (PDB id: 3dmp) and Bacillus caldolyticus (PDB id: 1i5e). For more details on the structure and function of this enzyme see Kadziola 2002.

    Ligand Summary





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