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    Table of contents
    1. 1. Protein Summary
    2. 2. Ligand Summary
    3. 3. References

    Title Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution. Proteins 54 810-813 2004
    Site JCSG
    PDB Id 1o51 Target Id 281902
    Molecular Characteristics
    Source Thermotoga maritima msb8
    Alias Ids TPS1178,TM0021, 83882 Molecular Weight 11803.24 Da.
    Residues 102 Isoelectric Point 6.41
    Sequence mkllkiylgekdkhsgkplfeylvkrayelgmkgvtvyrgimgfghkrhmhrsdffslspdlpivleiv deeerinlflkeidnidfdglvftadvnvvkmg
      BLAST   FFAS

    Structure Determination
    Method XRAY Chains 1
    Resolution (Å) 2.50 Rfree 0.229
    Matthews' coefficent 3.80 Rfactor 0.184
    Waters 39 Solvent Content 67.37

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    Ligand Information


    Google Scholar output for 1o51
    1. Contribution of Electrostatic Interactions, Compactness and Quaternary Structure to Protein Thermostability: Lessons from Structural Genomics of Thermotoga
    M Robinson-Rechavi, A Alibs, A Godzik - Journal of molecular biology, 2006 - Elsevier
    2. Crystal structure of a putative PII_like signaling protein (TM0021) from Thermotoga maritima at 2.5 resolution
    R Schwarzenbacher, F von Delft - Proteins: Structure, , 2004 - Wiley Online Library
    3. Identification of potential small molecule peptidomimetics similar to motifs in proteins
    I Baran, RS Varekova, L Parthasarathi - Journal of chemical , 2007 - ACS Publications
    4. The 2.2 resolution crystal structure of Bacillus cereus Nif3_family protein YqfO reveals a conserved dimetal_binding motif and a regulatory domain
    MH Godsey, G Minasov, L Shuvalova - Protein , 2007 - Wiley Online Library
    5. Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase
    J Siltberg-Liberles, A Martinez - Amino acids, 2009 - Springer
    6. The role of effector molecules in signal transduction by PII proteins
    M Radchenko, M Merrick - Biochemical Society , 2011 - test.biochemsoctrans.org
    7. Protein structural classification and family identification by multifractal analysis and wavelet spectrum
    SM Zhu, ZG Yu, A Vo - Chinese Physics B, 2011 - iopscience.iop.org
    8. Dimensionality reduction in computational demarcation of protein tertiary structures
    RR Joshi, PR Panigrahi, RN Patil - Journal of Molecular Modeling, 2011 - Springer
    9. Applications of Bioinformatics to Protein Structures: How Protein Structure and Bioinformatics Overlap
    GW Han, C Rife, MR Sawaya - Methods in Molecular Biology, 2009 - Springer
    10. PII signal transduction proteins: nitrogen regulation and beyond
    LF Huergo, G Chandra - FEMS Microbiology , 2012 - Wiley Online Library

    Protein Summary

    The TM0021 gene of Thermotoga maritima encodes a protein from the DUF190 group (PF02641; COG:COG1993) related to the nitrogen regulatory protein P-II (PFAM:PF00543; PMID:14997579, 16484197). The primary function of the PII family is to regulate the function of proteins involved in nitrogen metabolism in response to the carbon-nitrogen balance in the cell. Genome context analysis indicates a strong functional link (score 0.97) between TM0021 and TM0020, a crcB homolog.

    The TM0021 structure, 1o51, has a ferredoxin-like fold (SCOP sunid:54861) and belongs tothe GlnB-like superfamily, DUF190 family (SCOP sunid:54913). DALI hits are with the UPF0166 protein PH1503 PDB:2dcl (Z=16), the hypothetical protein TTHA0516 PDB:2cz4 (Z=11) and the P-II like signaling protein PDB:3dfe (Z=11).

    Ligand Summary





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