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PF12532

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF3732 PDB:
    Priority Score: 1.3
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 91 # architectures: 3 # taxonomy ids:71
    FFAS:
      Top FFAS hit in PDB: "3qkrB, DNA double-strand break repair rad50 ATPase" Top FFAS hit in Pfam: "PF13175, AAA ATPase domain "
    GRDB:
      Top significant hit (PDB90): "1w1wA, cohesin ; sc smc1hd:scc1-c complex, atpgs "
      Top significant hit (PFAM25U): "PF13514, AAA domain"
    PUBSERVER:
      Publications(s) found: 51
      Publications(s) meeting filtering criteria: 1
    GeneSilico Metaserver: (Login and password: Jamboree)
    PHYRE: PDB: 1ii8_B SCOP: predicted c.37.1
    MGENTHREADER: PDB: 1f2t_B
    HHBLITS: PDB: 1f2t_B
    COMPASS: PDB: 1ii8_B SCOP: predicted c.37.1
    HHSEARCH: PDB: 1f2t_B

    Topsan Members

    Tag pages as 'PF12532' to appear in this list.

    No TOPSAN member(s) found.

    Summary

    Proteins in this family are uncharacterised.  However the Pfam family as of release 26.0 appears to match to the C-terminal half of  P-loop domain.  I have extended the Pfam family to the whole length of the proteins. They are about 700 amino acids long and contain a large helical insert within the central region.  I think this is likely to form a coiled coil like the cohesin proteins.  Many of the proteins also contain a central CPXC motif that looks like the zinc hook found in the Rad50 protein and its homologues [Ref].  So it seems likely that these proteins dimerise to function.  Some members of this family are called Plasmid-related proteins so perhaps these are plasmid borne (I haven't checked) potentially involved in plasmid replication analogous to cohesins.

    Distant homologs of AAA domain (PF13514). This family is a member of clan P-loop_NTPase (CL0023).

    Reviews

    References

     

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