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PF12053

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF3534 PDB: 2ns5_A
    Solved by: non-psi Priority Score: 3.6
    Member of this family is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 112 # architectures: 9 # taxonomy ids:44
    FFAS:
      Top FFAS hit in PDB: "2ns5A, Partitioning-defective 3 homolog" Top FFAS hit in Pfam: "PF10407, Cdc14 phosphatase binding protein N-terminus "
    GRDB:
      Top significant hit (PDB90): "2ns5A, signaling protein ; the conserved n-terminal domain of par-3 adopts a novel pb1- like structure required for par-3 oligomerization and apical membrane localization "
      Top significant hit (PFAM25U): "PF10407, Cdc14 phosphatase binding protein N-terminus"
    PUBSERVER:
      Publications(s) found: 177
      Publications(s) meeting filtering criteria: 85
    GeneSilico Metaserver: (Login and password: Jamboree)
    FFAS: PDB: 2ns5_A SCOP: predicted d.15.1.1
    PHYRE: PDB: 2ns5_A SCOP: predicted d.15.1.1
    MGENTHREADER: PDB: 2ns5_A SCOP: predicted d.15.1.1
    HHBLITS: PDB: 2ns5_A SCOP: predicted d.15.1.1
    COMPASS: PDB: 2ns5_A SCOP: predicted d.15.1.1
    HHSEARCH: PDB: 2ns5_A SCOP: predicted d.15.1.1

    Topsan Members

    Tag pages as 'PF12053' to appear in this list.

    No TOPSAN member(s) found.

    Summary

    Metazoa-specific version of the PB1-type Beta grasp domains of the eukaryotic ubiquitin-like clade that mediates protein-protein interactions (http://www.ncbi.nlm.nih.gov/pubmed/17605815). It is always found at the N-termini of proteins and has been found to be required for oligomerization of proteins (http://www.ncbi.nlm.nih.gov/pubmed/17476308?dopt=Abstract). It  is found in conjunction with PDZ domains in the Par3 proteins and is required for its oligomerization.

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