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PF11838

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF3358 PDB: 1z1w_A
    Priority Score: 4.6
    Member of this family is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 2030 # architectures: 25 # taxonomy ids:522
    FFAS:
      Top FFAS hit in PDB: "1z1wA, Tricorn protease interacting factor F3" Top FFAS hit in Pfam: "PF11940, Domain of unknown function (DUF3458) "
    GRDB:
      Top significant hit (PDB90): "3qnfA, hydrolase ; crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 erap1 "
      Top significant hit (PFAM25U): "PF01347, Lipoprotein amino terminal region"
    CATH: CATH Domain E-value CATH Node
      1z1wA04 1.30E-58
      1lshA02 0.0055 1.25.10.20
      1oyzA00 0.01 1.25.10.10
    PUBSERVER:
      Publications(s) found: 1082
      Publications(s) meeting filtering criteria: 95
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2xdt_A ECC: 3.4.11.-
    BLASTP: PDB: 2xdt_A ECC: 3.4.11.-
    HHBLITS: PDB: 3se6_A ECC: 3.4.11.-
    COMPASS: PDB: 1z1w_A SCOP: predicted d.92.1 ECC: 3.4.11.-
    CSBLAST: PDB: 2xdt_A ECC: 3.4.11.-
    HHSEARCH: PDB: 3se6_A ECC: 3.4.11.-

    Topsan Members

    Tag pages as 'PF11838' to appear in this list.

    No TOPSAN member(s) found.

    Summary

    DUF3358 is an uncharacterized domain found at the C-terminus of zinc metallopeptidase belonging to MEROPS peptidase family M1. In ERAP1 this domain might be pulled away from the active site and thereby making it accessible to substrates.

    It is probably should be called Pept_M1_aminopeptidase_C or ERAP1_C.

    Reviews

    References

     

    No references found.

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