The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Pfam ID: DUF2026 PDB: 2hly_A
    Solved by: MCSG Priority Score: 1.6
    Member of this family is in PDB.
      # sequence matches: 9 # architectures: 1 # taxonomy ids:9
      Top FFAS hit in PDB: "2hlyA, Hypothetical protein Atu2299" Top FFAS hit in Pfam: "PF13471, Transglutaminase-like superfamily "
      Top significant hit (PDB90): "2hlyA, structural genomics, unknown function ; the crystal structure of genomics apc5867 "
    CATH: CATH Domain E-value CATH Node
      2hlyA00 1.20E-76 3.10.550.10
      Publications(s) found: 5
      Publications(s) meeting filtering criteria: 0
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2hly_A SCOP: d.3.1.19
    FFAS: PDB: 2hly_A SCOP: d.3.1.19
    MGENTHREADER: PDB: 2hly_A SCOP: d.3.1.19
    BLASTP: PDB: 2hly_A SCOP: d.3.1.19
    HHBLITS: PDB: 2hly_A SCOP: d.3.1.19
    COMPASS: PDB: 2hly_A SCOP: d.3.1.19
    CSBLAST: PDB: 2hly_A SCOP: d.3.1.19
    HHSEARCH: PDB: 2hly_A SCOP: d.3.1.19

    Topsan Members

    Tag pages as 'PF09641' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF09641 {Protein of unknown function (DUF2026) } with 1 members in NR database and additional 1 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id: TOPSAN:2hly) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1w5ra1 classified as Cysteine proteinases fold. Based on marginal prediction from FFAS confirmed by structural similarity one can argue that this family is remotely homologous to previously known structures from 'd1w5ra1' this fold. Based on fold and evidence of homology one can hypothesize that this family is probably involved in cleavage of peptide or ester bond




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