The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Topsan Members

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    Pfam family PFAM:PF08975 {Domain of unknown function (DUF1868)} with 105 members in NR database and additional 77 members in the metagenomic datasets is represented in Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:2fsq) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1iuha_ classified as Ligt-like fold. Based on marginal prediction from FFAS confirmed by structural similarity (possible only when domain boundaries are defined based on solved structure) one can argue that this family is remotely homologous to previously known structures from 'd1iuha_' this fold. Based on fold and evidence of homology one can hypothesize that this family is probably binds RNA




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