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PF08954

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF1900 PDB: 2aq5_A
    Solved by: non-psi Priority Score: 4.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 438 # architectures: 40 # taxonomy ids:170
    FFAS:
      Top FFAS hit in PDB: "2aq5A, Coronin-1A" No significant hits in Pfam.
    GRDB:
      Top significant hit (PDB90): "2aq5A, structural protein ; crystal structure of murine coronin-1 "
    FUNFAM (eval=0.000000023 ): p21-activated protein kinase-interacting protein 1 -like
    PUBSERVER:
      Publications(s) found: 256
      Publications(s) meeting filtering criteria: 69
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-
    FFAS: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-
    MGENTHREADER: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-
    BLASTP: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-
    COMPASS: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-
    CSBLAST: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-
    HHSEARCH: PDB: 2aq5_A SCOP: predicted b.69.4.1 ECC: predicted 2.3.-.-

    Topsan Members

    Tag pages as 'PF08954' to appear in this list.

    No TOPSAN member(s) found.

    Summary

    Not independent domain, part of a typical seven-bladed beta propeller topology, with the conserved region at the end of the last strand of the composite blade.

    Members include several coronins, which contain a conserved "KGD" motif in the DUF1900 domain that has been observed in other actin-binding proteins such as annexins and is a potential ligand for integrins and C2 domains known to be associated with structural and signalling roles in the membrane cytoskeleton [PMID:18925370].

    Reviews

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