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PF08950

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF1861 PDB: 2b4w_A
    Solved by: SGPP Priority Score: 1.6
    Member of this family is in PDB.
    HMMER:
      # sequence matches: 96 # architectures: 1 # taxonomy ids:30
    FFAS:
      Top FFAS hit in PDB: "2b4wA, hypothetical protein, conserved" Top FFAS hit in Pfam: "PF04041, Domain of unknown function (DUF377) "
    GRDB:
      Top significant hit (PDB90): "2b4wA, structural genomics, unknown function ; hypothetical protein from leishmania major "
      Top significant hit (PFAM25U): "PF04041, Domain of unknown function (DUF377)"
    CATH: CATH Domain E-value CATH Node
      2b4wA00 5.50E-118
      1vkdA00 1.70E-06 2.115.10.20
    PUBSERVER:
      Publications(s) found: 72
      Publications(s) meeting filtering criteria: 3
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2b4w_A SCOP: predicted b.67.2.5
    FFAS: PDB: 2b4w_A SCOP: predicted b.67.2.5
    MGENTHREADER: PDB: 2b4w_A SCOP: predicted b.67.2.5
    PRC: PDB: 2b4w_A SCOP: predicted b.67.2.5
    BLASTP: PDB: 2b4w_A SCOP: predicted b.67.2.5
    HHBLITS: PDB: 2b4w_A SCOP: predicted b.67.2.5
    COMPASS: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    CSBLAST: PDB: 2b4w_A SCOP: predicted b.67.2.5
    HHSEARCH: PDB: 2b4w_A SCOP: predicted b.67.2.5

    Topsan Members

    Tag pages as 'PF08950' to appear in this list.

    Name Annotation Author(s)
    2b4w

    Summary

    Pfam family PFAM:PF08950 {Protein of unknown function (DUF1861) } with 41 members in NR database and additional 5 members in the metagenomic datasets is represented in Archaea, Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:2b4w) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1vkda_ classified as 5-bladed beta-propeller fold. Profile-profile methods confirm remote homology between this family and superfamily of Arabinanase/levansucrase/invertase; 5-bladed beta-propeller fold. Based on remote homology confirmed by the structure one can hypothesize that this family is probably involved in sugar binding or nucleotide hydrolysis

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