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The Open Protein Structure Annotation Network
PDB Keyword
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PF06948

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Topsan Members

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    Name Annotation Author(s)
    2fb6
    Structure of BT1422 protein from Bacteroides thetaiotaomicron belongs to DsrEFH-like fold, found in a family of small proteins involved in intracellular sulfur reduction, as well as in a family of bac...

    Summary

    Pfam family PFAM:PF06948 {Protein of unknown function (DUF1291) } with 26 members in NR database and additional 17 members in the metagenomic datasets is represented in Archaea, and Bacteria. The first structural representative solved (PDB Id: TOPSAN:2fb6) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1l1sa_ classified as Dsrefh-like fold. (Note: new fold solved by PSI).  Profile-profile methods confirm a remote homology between this family and the superfamily of Dsrefh-like belonging to the fold of the same name. Based on remote homology confirmed by the structure, one can hypothesize that this family may be involved in sulfate binding and may play a role in sulfur oxidation.

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